N-cyclohexyl-3-phenylpropanamide

Base Information

• Chemical Name: N-cyclohexyl-3-phenylpropanamide
• CAS No.: 10264-23-0
• Molecular Formula: C15H21 N O
• Molecular Weight: 231.338
• Mol file: 10264-23-0.mol

Synonyms:Hydrocinnamamide,N-cyclohexyl- (7CI,8CI); NSC 155585

Chemical Property of N-cyclohexyl-3-phenylpropanamide

Chemical Property:

• Vapor Pressure: 1.9E-07mmHg at 25°C
• Boiling Point: 425.6°C at 760 mmHg
• Flash Point: 257.7°C
• Density: 1.03g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-cyclohexyl-3-phenylpropanamide

There total 32 articles about N-cyclohexyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexylamine (108-91-8,157973-60-9) + (S)-(2,3,4,5,6-pentafluorophenyl) 3-phenylpropanethioate (463298-63-7) → N-cyclohexyl-3-phenylpropionamide (10264-23-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1002/chem.200400754

Reference yield: 92.0%

(E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one (63677-96-3) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexyl-3-phenylpropionamide (10264-23-0)

Guidance literature:

With 1,2,4-Triazole; C₆H₁₀N₃O₂S⁽¹⁺⁾*Cl^(1-); N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 3h;

DOI:10.1039/b909360e

Reference yield: 88.0%

3-phenylpropionyltrimethylsilane (61157-31-1) + cyclohexyl azide (19573-22-9) → N-cyclohexyl-3-phenylpropionamide (10264-23-0)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.124

upstream raw materials:

3-bromo-3-phenyl-propionic acid cyclohexylamide

3-phenylpropanehydrazide

cyclohexylamine

(S)-(2,3,4,5,6-pentafluorophenyl) 3-phenylpropanethioate

Downstream raw materials:

N-(3-phenylpropyl)cyclohexanamine

Refernces

• 1、 Davidson, Robert W. M.,Fuchter, Matthew J.. "Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles". . p. 11638 - 11641. Retrieved 2016.
• 2、 -. "Method for selective reduction α, β - unsaturated carbonyl compound carbon-carbon double bond (by machine translation)". Paragraph 0119-0122. . Retrieved 2020/06/17.
• 3、 Guissart, Céline,Barros, Andre,Rosa Barata, Luis,Evano, Gwilherm. "Broadly Applicable Ytterbium-Catalyzed Esterification, Hydrolysis, and Amidation of Imides". supporting information. p. 5098 - 5102. Retrieved 2018/09/13.