1,2-Cyclopropanedicarboxylic acid, 1,2-diphenyl-, dimethyl ester, trans-

Base Information

• Chemical Name: 1,2-Cyclopropanedicarboxylic acid, 1,2-diphenyl-, dimethyl ester, trans-
• CAS No.: 111977-16-3
• Molecular Formula: C₁₉H₁₈O₄
• Molecular Weight: 310.35
• Mol file: 111977-16-3.mol

Synonyms:

Chemical Property of 1,2-Cyclopropanedicarboxylic acid, 1,2-diphenyl-, dimethyl ester, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Cyclopropanedicarboxylic acid, 1,2-diphenyl-, dimethyl ester, trans-

There total 1 articles about 1,2-Cyclopropanedicarboxylic acid, 1,2-diphenyl-, dimethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + trans-1,2-diphenylcyclopropane-1,2-dicarboxylic acid (736-88-9,896-59-3,93322-06-6) → (+/-)-1,2c-Diphenyl-cyclopropan-1r,2t-dicarbonsaeure-dimethylester (901-29-1,17160-34-8,111977-16-3)

Guidance literature:

With hydrogenchloride; for 48h; Heating;

DOI:10.1021/ja00210a031

Reference yield: 99.0%

(+/-)-1,2c-Diphenyl-cyclopropan-1r,2t-dicarbonsaeure-dimethylester (901-29-1,17160-34-8,111977-16-3) → trans-1,2-diphenyl-1,2-bis(hydromethyl)cyclopropane (17160-35-9,111977-17-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating; overnight;

DOI:10.1021/ja00210a031

Reference yield:

(+/-)-1,2c-Diphenyl-cyclopropan-1r,2t-dicarbonsaeure-dimethylester (901-29-1,17160-34-8,111977-16-3) → C33H30N4O4S2

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / LiAlH₄ / diethyl ether / Heating; overnight

2: pyridine / acetone / 0 deg C, 3 h then room t. overnight

3: 37.4 percent / KI / dimethylformamide / 336 h / 60 - 70 °C

4: 41 percent / 30percent aqueous KOH, 30percent H₂O₂ / ethanol / 96 h / Heating

5: 28.5 percent / polyphosphoric acid / Ambient temperature; overnight

6: 30 percent / methanol; H₂O / 168 h / Heating

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; PPA; dihydrogen peroxide; potassium iodide; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ja00210a031

upstream raw materials:

methanol

trans-1,2-diphenylcyclopropane-1,2-dicarboxylic acid

Downstream raw materials:

trans-1,2-diphenyl-1,2-bis(hydromethyl)cyclopropane

trans-1,2-diphenyl-1,2-dicyanomethylcyclopropane

trans-1,2-diphenylcyclopropane-1,2-diacetic acid

Methanesulfonic acid (1R,2R)-2-methanesulfonyloxymethyl-1,2-diphenyl-cyclopropylmethyl ester