N-Phenethylcarbamic acid isopropyl ester

Base Information

• Chemical Name: N-Phenethylcarbamic acid isopropyl ester
• CAS No.: 63982-24-1
• Molecular Formula: C12H17 N O2
• Molecular Weight: 207.272
• Mol file: 63982-24-1.mol

Synonyms:isopropyl N-phenethylcarbamate;Isopropyl-N-phenylethylcarbamate;propan-2-yl N-phenethylcarbamate;phenylethyl prop-2-yl carbamate;CARBAMIC ACID,PHENETHYL-,ISOPROPYL ESTER;Phenaethyl-carbamidsaeure-isopropylester;phenethyl-carbamic acid isopropyl ester;

Chemical Property of N-Phenethylcarbamic acid isopropyl ester

Chemical Property:

• Vapor Pressure: 0.000178mmHg at 25°C
• Boiling Point: 329.4°C at 760 mmHg
• Flash Point: 153°C
• PSA: 41.82000
• Density: 1.031g/cm³
• LogP: 2.56810

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenethylcarbamic acid isopropyl ester

There total 12 articles about N-Phenethylcarbamic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl-N-(2-phenethyl)carbamate (6970-83-8) + titanium(IV)isopropoxide (546-68-9) → isopropyl N-(2-phenylethyl)carbamate (63982-24-1)

Guidance literature:

In toluene; at 120 ℃; for 18h;

DOI:10.1021/jo971498z

Reference yield: 82.0%

benzyl (2-phenylethyl)carbamate (70867-38-8) + titanium(IV)isopropoxide (546-68-9) → isopropyl N-(2-phenylethyl)carbamate (63982-24-1)

Guidance literature:

In toluene; at 120 ℃; for 18h;

DOI:10.1021/jo971498z

Reference yield: 75.0%

phenethyl-carbamic acid prop-2-ynyl ester + titanium(IV) isopropylate (546-68-9) → isopropyl N-(2-phenylethyl)carbamate (63982-24-1) + phenethylamine (64-04-0)

Guidance literature:

With chloro-trimethyl-silane; magnesium; In tetrahydrofuran; at 50 ℃; for 24h;

DOI:10.1016/j.tetlet.2016.03.093

upstream raw materials:

N-(t-butoxycarbonyl)phenethylamine

titanium(IV)isopropoxide

ethyl-N-(2-phenethyl)carbamate

benzyl (2-phenylethyl)carbamate

Refernces

• 1、 Madhavan, Suchithra,Takagi, Hiromasa,Fukuda, Shunpei,Okamoto, Sentaro. "Low-valent titanium-catalyzed deprotection of allyl- and propargyl-carbamates to amines". . p. 2074 - 2077. Retrieved 2016/04/26.
• 2、 Chong, Pek Y.,Janicki, Slawomir Z.,Petillo, Peter A.. "Multilevel selectivity in the mild and high-yielding chlorosilane- induced cleavage of carbamates to isocyanates". . p. 8515 - 8521. Retrieved 2007/10/03.