2-(2,4-difluorophenyl)oxirane

Base Information

• Chemical Name: 2-(2,4-difluorophenyl)oxirane
• CAS No.: 111991-12-9
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.132
• Mol file: 111991-12-9.mol

Synonyms:2,4-Difluorophenyloxirane;

Chemical Property of 2-(2,4-difluorophenyl)oxirane

Chemical Property:

• Boiling Point: 162.0±40.0 °C(Predicted)
• PSA: 12.53000
• Density: 1.335±0.06 g/cm3(Predicted)
• LogP: 2.03610

Purity/Quality:

99% ^*data from raw suppliers

2-(2,4-Difluorophenyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,4-difluorophenyl)oxirane

There total 4 articles about 2-(2,4-difluorophenyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-bromo-2',4'-difluoroacetophenone (102429-07-2) → 2-(2,4-difluorophenyl)oxirane (111991-12-9)

Guidance literature:

2-bromo-2',4'-difluoroacetophenone; With sodium tetrahydroborate; In methanol; at 10 - 20 ℃; for 1h;

With potassium carbonate; at 20 ℃; for 1h;

Reference yield: 22.5%

2,4-difluorobenzaldehyde (399-53-1) → 2-(2,4-difluorophenyl)oxirane (111991-12-9)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 0 - 20 ℃; for 14h;

Reference yield:

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → 2-(2,4-difluorophenyl)oxirane (111991-12-9)

Guidance literature:

With sodium hydroxide; sodium borohydrid; In water;

upstream raw materials:

2-chloro-1-(2,4-dichlorophenyl)ethanone

2-bromo-2',4'-difluoroacetophenone

2,4-difluorobenzaldehyde

Downstream raw materials:

1-(2,4-difluorophenyl)-2-[(2-hydroxyethyl)amino]ethanol

tert-butyl [2-(2,4-difluorophenyl)-2-hydroxyethyl](2-hydroxyethyl)carbamate

tert-butyl 2-(2,4-difluorophenyl)morpholine-4-carboxylate

2-(2,4-difluorophenyl)morpholine

Refernces

• 1、 -. "METALLOENZYME INHIBITOR COMPOUNDS". Page/Page column 295-296. . Retrieved 2018/09/28.
• 2、 -. "NOVEL ALKYLAMINO DERIVATIVES". . . Retrieved 2008/06/13.