Technology Process of Propanoic acid, 2,2-dimethyl-,
4-benzoyl-2-(2-methyl-3-oxopropyl)phenyl ester
There total 7 articles about Propanoic acid, 2,2-dimethyl-,
4-benzoyl-2-(2-methyl-3-oxopropyl)phenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 41.6 g / NaI, K2CO3 / acetone / 96 h / Heating
2: 27.8 g / diethylaniline / 3.5 h / 207 - 218 °C
3: 36 g / pyridine / 2 h / 50 °C
4: 1.) 9-BBN, 2.) aq. NaOH, 30percent H2O2 / 1.) THF, 25 deg C, 3 h; 50 deg C, 1 h, 2.) THF, EtOH, 25 deg C, 2 h
5: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -50 - -60 deg C, 15 min, 2.) CH2Cl2, -50 deg C, 5 min
With
pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; dihydrogen peroxide; potassium carbonate; dimethyl sulfoxide; triethylamine; N,N-diethylaniline; sodium iodide;
In
acetone;
DOI:10.1021/jm00400a030
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
Yield given. Multistep reaction;
1.) CH2Cl2, -50 - -60 deg C, 15 min, 2.) CH2Cl2, -50 deg C, 5 min;
DOI:10.1021/jm00400a030
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 36 g / pyridine / 2 h / 50 °C
2: 1.) 9-BBN, 2.) aq. NaOH, 30percent H2O2 / 1.) THF, 25 deg C, 3 h; 50 deg C, 1 h, 2.) THF, EtOH, 25 deg C, 2 h
3: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -50 - -60 deg C, 15 min, 2.) CH2Cl2, -50 deg C, 5 min
With
pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; triethylamine;
DOI:10.1021/jm00400a030
