3-Pyridinecarboxylic acid, 5-(diphenoxyphosphinyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[methyl(phenylmethyl)amino]ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 5-(diphenoxyphosphinyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[methyl(phenylmethyl)amino]ethyl ester
• CAS No.: 112057-17-7
• Molecular Formula: C₃₆H₃₆N₃O₇P
• Molecular Weight: 653.671
• Mol file: 112057-17-7.mol

Synonyms:

Chemical Property of 3-Pyridinecarboxylic acid, 5-(diphenoxyphosphinyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[methyl(phenylmethyl)amino]ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 5-(diphenoxyphosphinyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[methyl(phenylmethyl)amino]ethyl ester

There total 5 articles about 3-Pyridinecarboxylic acid, 5-(diphenoxyphosphinyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[methyl(phenylmethyl)amino]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

2-ethyl 3-aminocrotonate (54527-73-0) + {1-[1-(3-Nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-propyl}-phosphonic acid diphenyl ester (112057-50-8,112076-50-3) → 2-(N-Benzyl-N-methylamino)-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-diphenoxyphosphinyl-1,4-dihydropyridine-3-carboxylate (112057-17-7)

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1248/cpb.35.3898

Reference yield:

1-(diphenylphosphoryl)propan-2-one (50523-18-7) → 2-(N-Benzyl-N-methylamino)-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-diphenoxyphosphinyl-1,4-dihydropyridine-3-carboxylate (112057-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine-AcOH salt / benzene / Heating

2: 18 percent / propan-2-ol / Heating

With piperdinium acetate; In isopropyl alcohol; benzene;

DOI:10.1248/cpb.35.3898

Reference yield:

diphenyl methyl phosphite (3577-87-5) → 2-(N-Benzyl-N-methylamino)-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-diphenoxyphosphinyl-1,4-dihydropyridine-3-carboxylate (112057-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.5 h / 120 °C

2: piperidine-AcOH salt / benzene / Heating

3: 18 percent / propan-2-ol / Heating

With piperdinium acetate; In isopropyl alcohol; benzene;

DOI:10.1248/cpb.35.3898

upstream raw materials:

2-ethyl 3-aminocrotonate

{1-[1-(3-Nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-propyl}-phosphonic acid diphenyl ester

1-(diphenylphosphoryl)propan-2-one

diphenyl methyl phosphite