ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS No.:112080-24-7
Molecular Formula:C14H14Cl2N2O2S
Molecular Weight:345.24400
Hs Code.:
Mol file:112080-24-7.mol

Synonyms:4-(2,3-Dichloro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property:

PSA：82.45000
LogP:4.00690

Purity/Quality:

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Technology Process of ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 4 articles about ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-97-9
ethyl acetoacetate

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 17356-08-0
thiourea

: 112080-24-7
Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With hydrogenchloride; In ethanol; for 0.0583333h; Irradiation;

Reference yield: 63.0%

: 68064-64-2,94739-24-9,68064-63-1
2-<(2,3-dichlorophenyl)methylene>-3-oxobutanoic acid ethyl ester

: 17356-08-0
thiourea

: 112080-24-7
Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: thiourea; With 1-methyl-pyrrolidin-2-one; resin bound 4-(benzyloxy)benzyl chloride; at 75 ℃; for 16h; solid phase reaction;

2-<(2,3-dichlorophenyl)methylene>-3-oxobutanoic acid ethyl ester; With 1-methyl-pyrrolidin-2-one; caesium carbonate; at 90 ℃; for 16h; solid phase reaction;

With trifluoroacetic acid; ethanethiol; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/S0960-894X(99)00572-7