ethyl 5-chloropyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 5-chloropyridine-3-carboxylate
• CAS No.: 20825-98-3
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Hs Code.: 2933399090
• Mol file: 20825-98-3.mol

Synonyms:ethyl 5-chloropyridine-3-carboxylate;

Chemical Property of ethyl 5-chloropyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.025mmHg at 25°C
• Boiling Point: 247.9°C at 760 mmHg
• Flash Point: 103.7°C
• PSA: 39.19000
• Density: 1.245g/cm³
• LogP: 1.91170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-chloronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-chloropyridine-3-carboxylate

There total 3 articles about ethyl 5-chloropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 3,5-dichloropyridine (2457-47-8) → 5-chloro-nicotinic acid ethyl ester (20825-98-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 100 ℃; under 5171.5 Torr;

DOI:10.1016/S0040-4039(01)81726-3

Reference yield:

trifluoromethanesulfonic acid 5-chloro-3-pyridinyl ester (150145-19-0) + ethanol (64-17-5) + carbon monoxide (201230-82-2) → 5-chloro-nicotinic acid ethyl ester (20825-98-3)

Guidance literature:

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In DMF (N,N-dimethyl-formamide); at 0 - 50 ℃; for 4h; under 760.051 Torr;

Reference yield:

→ 5-chloro-nicotinic acid ethyl ester (20825-98-3)

Guidance literature:

5-Chlor-nicotinsaeure, EtOH, HCl-Gas;

upstream raw materials:

ethanol

carbon monoxide

3,5-dichloropyridine

trifluoromethanesulfonic acid 5-chloro-3-pyridinyl ester

Downstream raw materials:

5-chloronicotinic acid

ethyl 5-hydroxy-3-pyridinecarboxylate

Ethyl 5-(3,4,5-trimethoxyphenyl)nicotinate

(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-chloro-pyridin-3-yl)-acrylamide