4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline

Base Information

Chemical Name:4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline
CAS No.:31009-33-3
Molecular Formula:C10H4BrF4N
Molecular Weight:294.046
Hs Code.:
NSC Number:142533
DSSTox Substance ID:DTXSID40301346
Nikkaji Number:J2.113.426K
Wikidata:Q72456610
Mol file:31009-33-3.mol

Synonyms:4-bromo-6-fluoro-2-(trifluoromethyl)quinoline;31009-33-3;4-bromo-6-fluoro-2(trifluoromethyl)quinoline;NSC142533;DTXSID40301346;JMZGVHLYCHYQEH-UHFFFAOYSA-N;MFCD11504912;AKOS015835387;NSC-142533;SB68810;BS-22291;CS-0450839;A876048

Suppliers and Price of 4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline
250mg
$ 55.00

Matrix Scientific
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline 95+%
1g
$ 284.00

Crysdot
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline 95+%
10g
$ 395.00

Chemenu
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline 95%
10g
$ 373.00

American Custom Chemicals Corporation
4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 95.00%
5MG
$ 503.03

Alichem
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline
10g
$ 402.99

Total 17 raw suppliers

Chemical Property of 4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline

Chemical Property:

Vapor Pressure:0.0099mmHg at 25°C
Melting Point:96-98 °C
Refractive Index:1.555
Boiling Point:272.9 °C at 760 mmHg
PKA:-2.07±0.50(Predicted)
Flash Point:118.8 °C
Density:1.722 g/cm³
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:292.94632
Heavy Atom Count:16
Complexity:258

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C(=CC(=N2)C(F)(F)F)Br

Technology Process of 4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline

There total 3 articles about 4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 587885-83-4,31009-34-4
6-fluoro-2-trifluoromethyl-4-quinolinone?

: 31009-33-3
4-bromo-6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: With phosphorus(V) oxybromide; at 150 ℃; for 2h;
DOI:10.1002/ejoc.200390217

Reference yield:

: 371-40-4
4-fluoroaniline

: 31009-33-3
4-bromo-6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / polyphosphoric acid / 2 h / 150 °C

2: 84 percent / phosphorus oxybromide / 2 h / 150 °C

With PPA; phosphorus(V) oxybromide;
DOI:10.1002/ejoc.200390217

Reference yield:

: 31009-33-3
4-bromo-6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: Vermutlich aus <6-Fluor-2-trifluormethyl-(4)chinolyl>-lithium u. Brom ( Angaben zur B. fehlen , vgl. S. 200 , 2. Spalte unten , Anm.8 );
DOI:10.1021/jm00285a005