6-Fluoro-2-trifluoromethylquinoline

Base Information

Chemical Name:6-Fluoro-2-trifluoromethylquinoline
CAS No.:587885-96-9
Molecular Formula:C10H5F4N
Molecular Weight:215.15
Hs Code.:
DSSTox Substance ID:DTXSID30454294
Wikidata:Q82275732
Mol file:587885-96-9.mol

Synonyms:6-FLUORO-2-TRIFLUOROMETHYLQUINOLINE;6-fluoro-2-(trifluoromethyl)quinoline;587885-96-9;SCHEMBL5833184;DTXSID30454294;GDUZDLJAUQBFFM-UHFFFAOYSA-N;Pyridine,5-(chloroMethyl)-2-(trifluoroMethyl)-(9CI)

Suppliers and Price of 6-Fluoro-2-trifluoromethylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-FLUORO-2-TRIFLUOROMETHYLQUINOLINE 95.00%
5MG
$ 499.31

Total 3 raw suppliers

Chemical Property of 6-Fluoro-2-trifluoromethylquinoline

Chemical Property:

PSA：12.89000
LogP:3.39270
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:215.03581181
Heavy Atom Count:15
Complexity:228

Purity/Quality:

95% ^*data from raw suppliers

6-FLUORO-2-TRIFLUOROMETHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=CC(=N2)C(F)(F)F)C=C1F

Technology Process of 6-Fluoro-2-trifluoromethylquinoline

There total 6 articles about 6-Fluoro-2-trifluoromethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 31009-33-3
4-bromo-6-fluoro-2-(trifluoromethyl)quinoline

: 587885-96-9
6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 0.25h;
DOI:10.1002/ejoc.200390217

Reference yield: 58.0%

: (2,2’-bipyridine)Zn(CF₃)₂

: 6-fluoro-1-(4-methoxybenzyl)quinolin-1-ium bromide

: 587885-96-9
6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: (2,2’-bipyridine)Zn(CF₃)₂; 6-fluoro-1-(4-methoxybenzyl)quinolin-1-ium bromide; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;

With ammonium cerium (IV) nitrate; In methanol; water; at 25 ℃; for 24h;
DOI:10.1016/j.tet.2021.132477

Reference yield: 48.0%

: 396-30-5
6-fluoroquinoline

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 587885-96-9
6-fluoro-2-(trifluoromethyl)quinoline

Guidance literature:: 6-fluoroquinoline; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydrogen difluoride; In 1,4-dioxane; at 25 ℃; for 0.00833333h;

(trifluoromethyl)trimethylsilane; With trifluoroacetic acid; In 1,4-dioxane; at 25 ℃; for 24h;

With [bis(acetoxy)iodo]benzene; In 1,4-dioxane; at 25 ℃; for 2h;
DOI:10.1021/acs.orglett.8b00339