Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate

Base Information

Chemical Name:Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate
CAS No.:112668-58-3
Molecular Formula:C23H19FN2O7
Molecular Weight:454.411
Hs Code.:

Synonyms:

Suppliers and Price of Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate

There total 21 articles about Uridine, 3'-deoxy-3'-fluoro-, 2',5'-dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 123484-12-8
((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate

: 3442-82-8
1,3-bis(trimethylsilyl)uracil

: 112668-58-3
1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil

: 133776-12-2
C₂₃H₁₉FN₂O₇

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; for 22h; Ambient temperature;
DOI:10.1021/jm00111a040

Reference yield:

: 14980-09-7
methyl 5-O-benzyl-3-fluoro-3-deoxy-α-D-arabino-furanoside

: 112668-58-3
1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / pyridine / 28 h / Ambient temperature

2: 33.6 percent / dibenzo-18-crown-6 / dimethylsulfoxide / 7 h / 205 - 210 °C

3: 97 percent / H₂ / 10percent Pd/C / ethanol / 72 h / Ambient temperature

4: 94 percent / pyridine / 12 h / Ambient temperature

5: 94 percent / concd. H₂SO₄, AcOH / 20 h / Ambient temperature

6: 70 percent / SnCl₄ / 1,2-dichloro-ethane / 22 h / Ambient temperature

With pyridine; dibenzo-18-crown-6; sulfuric acid; hydrogen; tin(IV) chloride; acetic acid; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm00111a040

Reference yield:

: 14645-49-9
methyl 2,3-anhydro-5-O-benzyl-α-D-lyxofuranoside

: 112668-58-3
1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 7 steps

1: 45 percent / KHF₂, NaF / ethane-1,2-diol / 4 h / Heating

2: 93 percent / pyridine / 28 h / Ambient temperature

3: 33.6 percent / dibenzo-18-crown-6 / dimethylsulfoxide / 7 h / 205 - 210 °C

4: 97 percent / H₂ / 10percent Pd/C / ethanol / 72 h / Ambient temperature

5: 94 percent / pyridine / 12 h / Ambient temperature

6: 94 percent / concd. H₂SO₄, AcOH / 20 h / Ambient temperature

7: 70 percent / SnCl₄ / 1,2-dichloro-ethane / 22 h / Ambient temperature

With pyridine; dibenzo-18-crown-6; potassium hydrogen bifluoride; sulfuric acid; hydrogen; tin(IV) chloride; sodium fluoride; acetic acid; palladium on activated charcoal; In ethanol; ethylene glycol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm00111a040