3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate

Base Information

• Chemical Name: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate
• CAS No.: 123484-12-8
• Molecular Formula: C₂₁H₁₉FO₇
• Molecular Weight: 402.376
• Mol file: 123484-12-8.mol

Synonyms:((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate

Chemical Property of 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-O -Acetyl-2,5-di-O-benzoyl-3-fluoro-3-deoxy-D-ribofuranoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate

There total 35 articles about 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

acetic anhydride (108-24-7) + methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-α-D-ribofuranoside (126716-27-6) → ((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate (123484-12-8)

Guidance literature:

With sulfuric acid; acetic acid; for 20h; Ambient temperature;

DOI:10.1021/jm00111a040

Reference yield: 90.0%

((2R,3R,4S)-4-(benzoyloxy)-3-fluoro-5-methoxytetrahydrofuran-2-yl)methyl benzoate → ((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate (123484-12-8)

Guidance literature:

With sulfuric acid; acetic anhydride; acetic acid; at 20 ℃; for 16h;

Reference yield: 89.0%

acetic anhydride (108-24-7) + methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-β-D-ribofuranoside (112695-36-0) → ((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate (123484-12-8)

Guidance literature:

With sulfuric acid; acetic acid; for 20h; Ambient temperature;

DOI:10.1021/jm00111a040

upstream raw materials:

acetic anhydride

methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-β-D-ribofuranoside

methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-α-D-ribofuranoside

methyl 3-fluoro-α-D-3-deoxy-arabinofuranoside

Downstream raw materials:

N6-benzoyl-9-(2'-O-benzoyl-3'-deoxy-3'-fluoro-β-D-ribofuranosyl)adenine

3'-deoxy-3'-fluorocytidine

2-amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purine-6-one

1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil