N-(4-chlorophenyl)-N-{4-methyl-5-[5-(2-pyridinyl)-4,5-dihydro-3-isoxazolyl]-1,3-thiazol-2-yl}amine

Base Information

• Chemical Name: N-(4-chlorophenyl)-N-{4-methyl-5-[5-(2-pyridinyl)-4,5-dihydro-3-isoxazolyl]-1,3-thiazol-2-yl}amine
• CAS No.: 112834-45-4
• Molecular Formula: C18H15ClN4OS
• Molecular Weight: 370.85600
• Mol file: 112834-45-4.mol

Synonyms:

Chemical Property of N-(4-chlorophenyl)-N-{4-methyl-5-[5-(2-pyridinyl)-4,5-dihydro-3-isoxazolyl]-1,3-thiazol-2-yl}amine

Chemical Property:

• PSA: 87.64000
• LogP: 4.61780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chlorophenyl)-N-{4-methyl-5-[5-(2-pyridinyl)-4,5-dihydro-3-isoxazolyl]-1,3-thiazol-2-yl}amine

There total 3 articles about N-(4-chlorophenyl)-N-{4-methyl-5-[5-(2-pyridinyl)-4,5-dihydro-3-isoxazolyl]-1,3-thiazol-2-yl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-1-[2-(4-Chloro-phenylamino)-4-methyl-thiazol-5-yl]-3-pyridin-2-yl-propenone (112833-35-9) → (4-Chloro-phenyl)-[4-methyl-5-(5-pyridin-2-yl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine (112834-45-4)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In ethanol; for 4h; Heating;

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → (4-Chloro-phenyl)-[4-methyl-5-(5-pyridin-2-yl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine (112834-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 40percent potassium hydroxide / ethanol / 24 h / Ambient temperature

2: 90 percent / hydroxylamine hydrochloride, potassium hydroxide / ethanol / 4 h / Heating

With potassium hydroxide; hydroxylamine hydrochloride; In ethanol;

Reference yield:

1-(2-((4-chlorophenyl)amino)-4-methyl-1,3-thiazol-5-yl)ethan-1-one (71047-49-9) → (4-Chloro-phenyl)-[4-methyl-5-(5-pyridin-2-yl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine (112834-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 40percent potassium hydroxide / ethanol / 24 h / Ambient temperature

2: 90 percent / hydroxylamine hydrochloride, potassium hydroxide / ethanol / 4 h / Heating

With potassium hydroxide; hydroxylamine hydrochloride; In ethanol;

upstream raw materials:

(E)-1-[2-(4-Chloro-phenylamino)-4-methyl-thiazol-5-yl]-3-pyridin-2-yl-propenone

pyridine-2-carbaldehyde

1-(2-((4-chlorophenyl)amino)-4-methyl-1,3-thiazol-5-yl)ethan-1-one

Refernces