Benzenemethanesulfinic acid, a-phenyl-a-(trifluoromethyl)-, 2,2-dimethylpropyl ester

Base Information

• Chemical Name: Benzenemethanesulfinic acid, a-phenyl-a-(trifluoromethyl)-, 2,2-dimethylpropyl ester
• CAS No.: 112882-01-6
• Molecular Formula: C₁₉H₂₁F₃O₂S
• Molecular Weight: 370.436
• Mol file: 112882-01-6.mol

Synonyms:

Chemical Property of Benzenemethanesulfinic acid, a-phenyl-a-(trifluoromethyl)-, 2,2-dimethylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanesulfinic acid, a-phenyl-a-(trifluoromethyl)-, 2,2-dimethylpropyl ester

There total 6 articles about Benzenemethanesulfinic acid, a-phenyl-a-(trifluoromethyl)-, 2,2-dimethylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 2,2,2-Trifluoro-1,1-diphenyl-ethanesulfinic acid 2,2-dimethyl-propyl ester (112882-01-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) Mg / 1.) ether, 2.) reflux, 1 h

2: 1.) NaH / 1.) ether, room temp., 1 h, 2.) room temp., 70 h

3: 96 percent / H₂S, p-TsOH / various solvent(s) / 1 h / 60 °C

4: 96 percent / sulfuryl chloride / diethyl ether / 0.25 h / Ambient temperature

5: 100 percent / CF₃CO₃H / CH₂Cl₂ / 0 deg C, 1 h; room temp., 1 h

6: N-methylimidazole / 0 deg C to room temp.

With 1-methyl-1H-imidazole; sulfuryl dichloride; trifluoroacetyl peroxide; hydrogen sulfide; sodium hydride; toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane;

DOI:10.1055/s-1987-28045

Reference yield:

1,1-diphenyl-2,2,2-trifluoroethanol (379-18-0) → 2,2,2-Trifluoro-1,1-diphenyl-ethanesulfinic acid 2,2-dimethyl-propyl ester (112882-01-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) ether, room temp., 1 h, 2.) room temp., 70 h

2: 96 percent / H₂S, p-TsOH / various solvent(s) / 1 h / 60 °C

3: 96 percent / sulfuryl chloride / diethyl ether / 0.25 h / Ambient temperature

4: 100 percent / CF₃CO₃H / CH₂Cl₂ / 0 deg C, 1 h; room temp., 1 h

5: N-methylimidazole / 0 deg C to room temp.

With 1-methyl-1H-imidazole; sulfuryl dichloride; trifluoroacetyl peroxide; hydrogen sulfide; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1055/s-1987-28045

Reference yield:

2,2,2-trifluoro-1,1-diphenylethane-sulfenyl chloride (112881-92-2) → 2,2,2-Trifluoro-1,1-diphenyl-ethanesulfinic acid 2,2-dimethyl-propyl ester (112882-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CF₃CO₃H / CH₂Cl₂ / 0 deg C, 1 h; room temp., 1 h

2: N-methylimidazole / 0 deg C to room temp.

With 1-methyl-1H-imidazole; trifluoroacetyl peroxide; In dichloromethane;

DOI:10.1055/s-1987-28045

upstream raw materials:

2,2-dimethyl-propanol-1

2,2,2-Trifluoro-1,1-diphenylethanesulfinyl chloride

bromobenzene

1,1-diphenyl-2,2,2-trifluoroethanol