Methanesulfonic acid, trifluoro-, 3-amino-2-ethenylphenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 3-amino-2-ethenylphenyl ester
• CAS No.: 112970-63-5
• Molecular Formula: C9H8F3NO3S
• Molecular Weight: 267.229
• Mol file: 112970-63-5.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 3-amino-2-ethenylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 3-amino-2-ethenylphenyl ester

There total 4 articles about Methanesulfonic acid, trifluoro-, 3-amino-2-ethenylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-ethenyl-3-nitrophenyl trifluoromethanesulfonate (112970-62-4) → 2-vinyl-3-aminophenyl trifluoromethanesulfonate (112970-63-5)

Guidance literature:

With iron; In ethanol; acetic acid; Heating;

DOI:10.1021/jo00241a010

Reference yield:

2-Amino-3-nitrophenol (603-85-0) → 2-vinyl-3-aminophenyl trifluoromethanesulfonate (112970-63-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) hydrobromic acid, sodium nitrite, 2.) coopper(I) bromide / 1.) water, 1,4-dioxane, 0 deg C, 15 min, 2.) a) 0 deg C, 15 min, b) 60 deg C, 15 min

2: 54 percent / pyridine, / CH₂Cl₂ / 24 h / 0 - 20 °C

3: 91 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 48 h / Heating

4: 80 percent / iron / acetic acid; ethanol / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; iron; copper(I) bromide; sodium nitrite; In ethanol; dichloromethane; acetic acid; toluene;

DOI:10.1021/jo00241a010

Reference yield:

2-bromo-3-hydroxy-1-nitrobenzene (101935-40-4) → 2-vinyl-3-aminophenyl trifluoromethanesulfonate (112970-63-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / pyridine, / CH₂Cl₂ / 24 h / 0 - 20 °C

2: 91 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 48 h / Heating

3: 80 percent / iron / acetic acid; ethanol / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; In ethanol; dichloromethane; acetic acid; toluene;

DOI:10.1021/jo00241a010

upstream raw materials:

2-ethenyl-3-nitrophenyl trifluoromethanesulfonate

2-Amino-3-nitrophenol

2-bromo-3-hydroxy-1-nitrobenzene

2-bromo-3-nitrophenyl trifluoromethanesulfonate

Downstream raw materials:

4-<(E)-2-carbethoxyvinyl>-N-tosylindole

1-tosyl-4-vinyl-1H-indole

4-<<(trifluoromethyl)sulfonyl>oxy>-N-tosylindole

1-(1-tosyl-1H-indol-4-yl)ethanone