2-chloro-6-Methylquinazoline

Base Information

• Chemical Name: 2-chloro-6-Methylquinazoline
• CAS No.: 113082-39-6
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.621
• Hs Code.: 2933990090
• Mol file: 113082-39-6.mol

Synonyms:

Chemical Property of 2-chloro-6-Methylquinazoline

Chemical Property:

• Boiling Point: 269.8±23.0 °C(Predicted)
• PKA: 0.36±0.30(Predicted)
• PSA: 25.78000
• Density: 1.292
• LogP: 2.59160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-6-methylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-Methylquinazoline

There total 3 articles about 2-chloro-6-Methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

6-methyl-2,4-dichloroquinazoline (39576-82-4) → 2-chloro-6-methylquinazoline (113082-39-6)

Guidance literature:

With ammonium hydroxide; sodium chloride; zinc; In dichloromethane; at 50 ℃; for 5h;

Reference yield:

2-Amino-5-methylbenzoic acid (2941-78-8) → 2-chloro-6-methylquinazoline (113082-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h / 200 °C

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 120 °C

3: sodium chloride; ammonium hydroxide; zinc / dichloromethane / 5 h / 50 °C

With ammonium hydroxide; N,N-dimethyl-aniline; sodium chloride; zinc; trichlorophosphate; In dichloromethane;

Reference yield:

6-methyl-1H-quinazoline-2,4-dione (62484-16-6) → 2-chloro-6-methylquinazoline (113082-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 120 °C

2: sodium chloride; ammonium hydroxide; zinc / dichloromethane / 5 h / 50 °C

With ammonium hydroxide; N,N-dimethyl-aniline; sodium chloride; zinc; trichlorophosphate; In dichloromethane;

upstream raw materials:

2-Amino-5-methylbenzoic acid

6-methyl-1H-quinazoline-2,4-dione

6-methyl-2,4-dichloroquinazoline

Refernces