39576-82-4

Basic information

• Product Name: 2,4-DICHLORO-6-METHYLQUINAZOLINE
• Synonyms: 2,4-DICHLORO-6-METHYLQUINAZOLINE;6-Methyl-2,4-dichloroquinazoline;EOS-60385
• CAS NO: 39576-82-4
• Molecular Formula: C₉H₆Cl₂N₂
• Molecular Weight: 213.07
• Mol File: 39576-82-4.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 226.8 °C at 760 mmHg
• Flash Point: 112.678 °C
• Appearance: /Solid
• Density: 1.419 g/cm³
• Vapor Pressure: 0.121mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.30±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-6-METHYLQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-6-METHYLQUINAZOLINE(39576-82-4)
• EPA Substance Registry System: 2,4-DICHLORO-6-METHYLQUINAZOLINE(39576-82-4)

Safety Data

• Hazardous Substances Data: 39576-82-4(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-6-methylquinazoline is a chemical compound with the molecular formula C9H6Cl2N2. It is a white to light yellow crystalline powder that is primarily used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. 2,4-DICHLORO-6-METHYLQUINAZOLINE has been found to exhibit herbicidal and anti-cancer properties, and is being researched for its potential use in the treatment of various diseases. Additionally, 2,4-dichloro-6-methylquinazoline has been studied for its potential as a building block for the synthesis of novel molecules with biological activity. Its versatile nature and potential applications make it an important compound in the chemical and pharmaceutical industries.

InChI:InChI=1/C9H6Cl2N2/c1-5-2-3-7-6(4-5)8(10)13-9(11)12-7/h2-4H,1H3

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 57-13-6 urea 
• 784183-53-5 2,2,2-trifluoro-N-(2-iodo-4-methylphenyl)acetamide 
• 29289-13-2 2-iodo-4-methylaniline 
• 150893-79-1 N-(2-cyano-4-methyl-phenyl)-2,2,2-trifluoro-acetamide 
• 5925-93-9 2-amino-5-methylbenzonitrile 
• 503-38-8 trichloromethyl chloroformate 
• 62484-16-6 6-methyl-1H-quinazoline-2,4-dione 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 62484-42-8 2-Chloro-3,4-dihydro-4-oxo-6-methylquinazoline 
• 94207-37-1 N-benzyl-2-chloro-6-methylquinazolin-4-amine 
• 1422500-60-4 N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine 
• 1123685-30-2 N-[(1R,2S)-2-((2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl)amino)cyclohexyl]-N',N-bis(tert-butoxycarbonyl)guanidine 
• 620957-75-7 N-((1R,2S)-2-[(2-amino-6-methylquinazolin-4-yl)-amino]cyclohexyl)-N',N''-bis(tert-butoxycarbonyl)guanidine 
• 620957-79-1 tert-butyl [(1R,2S)-2-((2-[(4-methoxybenzyl)amino]-6-methylquinazolin-4-yl)amino)cyclohexyl]carbamate 
• 620957-80-4 (1R,2S)-2-[(2-amino-6-methylquinazolin-4-yl)amino]-cyclohexylamine 
• 113082-39-6 2-chloro-6-methylquinazoline 
• 1356125-25-1 N-(4-fluorobenzyl)-4-[[(2-(dimethylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-24-0 N-(6-chloropyridin-3-yl)-4-[[(2-(propylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 

Relevant articles and documents

One-pot cascade ring enlargement of isatin-3-oximes to 2,4-dichloroquinazolines mediated by bis(trichloromethyl)carbonate and triarylphosphine oxide

An efficient and convenient one-pot cascade synthesis of 2,4-dichloroquinazolines directly from isatin-3-oximes with the addition of bis(trichloromethyl)carbonate and triarylphosphine oxide was developed, leading to substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a range of functional groups. Thus, the method represents a convenient and practical strategy for the synthesis of substituted 2,4-dichloroquinazolines.

AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Synthesis and Antibacterial Activity of Sulfur-linked Bis and Tris Heterocycles

The bis and tris heterocycles-benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines linked by sulfur and/or nitrogen were prepared from 2,4-dichloroquinazoline and benzazolyl-2-thiol/benzazolyl-2-amine and studied their antibacterial activity. The nitro-substituted sulfur-linked bisbenzothiazolylquinazoline (12f), bisbenzimidazolylquinazoline (13f), and nitro-substituted sulfur and nitrogen-linked bisbenzothiazolylquinazoline (15f) were found to be potential antibacterial agents against Staphylococcus aureus.