62484-16-6

Basic information

• Product Name: 2,4(1H,3H)-Quinazolinedione, 6-methyl-
• Synonyms: 2,4(1H,3H)-Quinazolinedione, 6-methyl-;6-Methylquinazoline-2,4(1H,3H)-dione;6-Methylquinazoline-2,4-diol;6-Methyl-1H-quinazoline-2,4-quinone;6-Methyl-1,2,3,4-tetrahydro-2,4-quinazolinedione;NSC 338219;6-methyl-1H-quinazoline-2,4-dione
• CAS NO: 62484-16-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.18
• Mol File: 62484-16-6.mol
• Article Data: 36

Chemical Properties

• Melting Point: 314-316℃
• Appearance: Off-white/Solid
• Density: 1.28 g/cm³
• Refractive Index: 1.576
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.19±0.20(Predicted)
• CAS DataBase Reference: 2,4(1H,3H)-Quinazolinedione, 6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Quinazolinedione, 6-methyl-(62484-16-6)
• EPA Substance Registry System: 2,4(1H,3H)-Quinazolinedione, 6-methyl-(62484-16-6)

Safety Data

• Hazardous Substances Data: 62484-16-6(Hazardous Substances Data)

Usage

General Description

6-methyl-2,4(1H,3H)-Quinazolinedione is a chemical compound with the molecular formula C9H8N2O2. 2,4(1H,3H)-Quinazolinedione, 6-methyl- is a quinazolinedione derivative, which is a type of heterocyclic compound containing two nitrogen atoms within the ring structure. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential biological and pharmacological activities, including antiviral, antimicrobial, and anti-cancer properties. The 6-methyl substitution on the quinazolinedione ring may impact its chemical and biological properties, making it a potentially useful compound in various applications.

InChI:InChI=1/C9H8N2O2/c1-5-2-3-7-6(4-5)8(12)11-9(13)10-7/h2-4H,1H3,(H2,10,11,12,13)

Upstream product

• 85474-13-1 6-methyl-3-amino-2,4(1H,3H)-quinazolinedione 
• 590-28-3 potassium cyanate 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 608-05-9 5-methyl-indole-2,3-dione 
• 617-84-5 N-formyldiethylamine 
• 5925-93-9 2-amino-5-methylbenzonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 57-13-6 urea 
• 124-38-9 carbon dioxide 

Downstream Products

• 39576-82-4 6-methyl-2,4-dichloroquinazoline 
• 94207-37-1 N-benzyl-2-chloro-6-methylquinazolin-4-amine 
• 113082-39-6 2-chloro-6-methylquinazoline 
• 1356125-25-1 N-(4-fluorobenzyl)-4-[[(2-(dimethylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-03-5 N-(4-fluorobenzyl)-4-[[(2-chloro-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-02-4 N-(6-chloropyridin-3-yl)-4-[[(2-chloro-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-24-0 N-(6-chloropyridin-3-yl)-4-[[(2-(propylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-23-9 N-(6-chloropyridin-3-yl)-4-[[(2-(dimethylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-22-8 N-(4-fluorophenyl)-4-[[6-methyl-(2-(allylamino)quinazolin-4-yl)amino]methyl]benzamide 
• 1356125-35-3 N-[1-(4-fluorobenzoyl)piperidin-4-yl]-4-[[(2-(allylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-34-2 N-[1-(4-fluorobenzoyl)piperidin-4-yl]-4-[[(2-(propylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-06-8 N-[1-(4-fluorobenzoyl)piperidin-4-yl]-4-[[(2-chloro-6-methylquinazolin-4-yl)amino]methyl]benzamide 
• 1356125-31-9 N-(4-fluorophenethyl)-4-[[(2-(propylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide 

Relevant articles and documents

Proton type ionic liquid [HDBN] [2-PyOH] and preparation and application thereof

The invention discloses proton type ionic liquid [HDBN] [2-PyOH] and preparation and application thereof, and belongs to the technical field of catalysts. The preparation method comprises the steps that 1, 5-diazabicyclo [4.3. 0] nonyl-5-ene reacts with 2-hydroxypyridine to prepare protonic ionic liquid [HDBN] [2-PyOH]; and as a catalyst, the ionic liquid can catalyze CO2 and o-aminobenzonitrile compounds to efficiently react under mild conditions to obtain a series of quinazoline-2, 4 (1H, 3H)-diketone compounds. The proton type ionic liquid catalyst has the advantages of simple synthesis process, excellent catalytic performance, good substrate expansion capability, easy product separation and the like, and has a good industrial application prospect.

Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria. This target was pursed for the development of new antibacterial agents against multiresistant pathogens. We have developed a new class of ANPs based on the mimic of two natural's cofactors (dUMP and FAD) as inhibitors against Mycobacterium tuberculosis ThyX. Several synthetic efforts were performed to optimize regioselective N1-alkylation, cross-coupling metathesis and Sonogashira cross-coupling. Compound 19c showed a poor 31.8% inhibitory effect on ThyX at 200 μM.

Efficient synthesis of 2-oxazolidinones and quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by tetrabutylammonium fluoride

By employing tetrabutylammonium fluoride (TBAF) as a catalyst, the various carboxylative cyclizations of the propargylic amines having internal alkynes with CO2 proceeded to afford the corresponding 2-oxazolidinones. In this case, it was also found that the generated 2-oxazolidinones were tautomerized into the corresponding 2-oxazolones due to the basicity of TBAF. In addition, we performed the synthesis of quinazoline-2,4(1H,3H)-dione from 2-aminobenzonitrile and CO2 by using TBAF as a catalyst.