alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol

Base Information

• Chemical Name: alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol
• CAS No.: 70263-43-3
• Molecular Formula: C14H12BrNO
• Molecular Weight: 290.159
• European Community (EC) Number: 274-519-8
• DSSTox Substance ID: DTXSID20990474
• Nikkaji Number: J288.906D
• Mol file: 70263-43-3.mol

Synonyms:70263-43-3;alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol;EINECS 274-519-8;SCHEMBL11293244;DTXSID20990474;AKOS005216557;1-(4-bromophenyl)-1-pyridin-3-ylprop-2-en-1-ol;alpha-(4-Bromophenyl)-alpha-ethenyl-3-pyridinemethanol;1-(4-BROMOPHENYL)-1-(PYRIDIN-3-YL)PROP-2-EN-1-OL

Chemical Property of alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol

Chemical Property:

• Boiling Point: 430.163oC at 760 mmHg
• Flash Point: 213.955oC
• PSA: 33.12000
• Density: 1.417g/cm3
• LogP: 3.26600
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 289.01023
• Heavy Atom Count: 17
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C=CC(C1=CC=C(C=C1)Br)(C2=CN=CC=C2)O

Technology Process of alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol

There total 5 articles about alpha-(4-Bromophenyl)-alpha-vinylpyridine-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Vinyl bromide (593-60-2,25951-54-6) + (4-bromophenyl)-pyridin-3-yl-methanone (14548-45-9) + vinyl magnesium bromide (1826-67-1) + ammonium chloride → 1-(4-Bromophenyl)-1-(3-pyridyl)-2-propen-1-ol (70263-43-3)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield:

(4-bromophenyl)-pyridin-3-yl-methanone (14548-45-9) + ammonium chloride + vinylmagnesium chloride (3536-96-7) → 1-(4-Bromophenyl)-1-(3-pyridyl)-2-propen-1-ol (70263-43-3)

Guidance literature:

In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

Vinyl bromide (593-60-2,25951-54-6) + (4-bromophenyl)-pyridin-3-yl-methanone (14548-45-9) → 1-(4-Bromophenyl)-1-(3-pyridyl)-2-propen-1-ol (70263-43-3)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) THF, reflux, 1 h, 2.) THF, room temp., 2 h;

DOI:10.1021/jo00330a019

upstream raw materials:

Vinyl bromide

(4-bromophenyl)-pyridin-3-yl-methanone

3-pyridinecarbonyl chloride

bromobenzene

Downstream raw materials:

Acetic acid 1-(4-bromo-phenyl)-1-pyridin-3-yl-allyl ester

(E)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol

(Z)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol

(Z)-3-(4-bromophenyl)-3-(3-pyridyl) allyl chloride

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