1-Pyrrolidineacetic acid, a-(4-chlorophenyl)-

Base Information

• Chemical Name: 1-Pyrrolidineacetic acid, a-(4-chlorophenyl)-
• CAS No.: 113346-67-1
• Molecular Formula: C₁₂H₁₄ClNO₂
• Molecular Weight: 239.702
• Mol file: 113346-67-1.mol

Synonyms:

Chemical Property of 1-Pyrrolidineacetic acid, a-(4-chlorophenyl)-

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

2-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidineacetic acid, a-(4-chlorophenyl)-

There total 4 articles about 1-Pyrrolidineacetic acid, a-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.9%

methyl 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)acetate → 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)acetic acid (113346-67-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 4h;

DOI:10.1016/j.bioorg.2020.103671

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) → 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)acetic acid (113346-67-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 5 h / 60 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Reflux

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C

4: sodium hydroxide; water / ethanol / 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrachloromethane; ethanol; acetonitrile;

DOI:10.1016/j.bioorg.2020.103671

Reference yield:

(4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) → 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)acetic acid (113346-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C

3: sodium hydroxide; water / ethanol / 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrachloromethane; ethanol; acetonitrile;

DOI:10.1016/j.bioorg.2020.103671

upstream raw materials:

4-chlorophenylacetic Acid

(4-chloro-phenyl)-acetic acid methyl ester

methyl 2-bromo-2-(4-chlorophenyl)acetate