5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Base Information

• Chemical Name: 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine
• CAS No.: 39243-92-0
• Molecular Formula: C12H12N2
• Molecular Weight: 184.2371
• Mol file: 39243-92-0.mol

Synonyms:4H-Pyrrolo(1,2-a)(1,4)benzodiazepine,5,6-dihydro;Pyrrolobenzodiazepin;4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina;5,6-dihydro-4H-benzo[f]pyrrolo[1,2-a][1,4]diazepine;5,6-Dihydro-4H-pyrrolo(1,2-a)(1,4)benzodiazepine;4,5-Dihydro-6H-pyrrol-<1,2-a><1,4>-benzodiazepin;4,5-Diidro-6H-pirrolo(1,2-a)(1,4)benzodiazepina [Italian];

Chemical Property of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Chemical Property:

• Vapor Pressure: 6.42E-05mmHg at 25°C
• Boiling Point: 344.8°Cat760mmHg
• Flash Point: 162.3°C
• PSA: 16.96000
• Density: 1.18g/cm³
• LogP: 2.40930

Purity/Quality:

5,6-dihydro-4H-Pyrrolo[1,2-a][1,4]benzodiazepine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

There total 4 articles about 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate (79100-16-6) → 4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina (39243-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 40.6 percent / hydroxlamine chlorohydrate / pyridine; aq. ethanol / 0.5 h / Heating

2: 75 percent / hydrogen / 10percent Pd/C / ethanol / 45 °C / 3040 Torr

3: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; hydroxlamine chlorohydrate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol;

Reference yield:

1-(2-metossicarbonilfenil)pirrolo-2-carbaldossima (92508-14-0) → 4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina (39243-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / hydrogen / 10percent Pd/C / ethanol / 45 °C / 3040 Torr

2: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

Reference yield:

6-cheto-4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina (92508-15-1) → 4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina (39243-92-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

upstream raw materials:

6-cheto-4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina

methyl 2-(2-formyl-1H-pyrrol-1-yl)benzenecarboxylate

1-(2-metossicarbonilfenil)pirrolo-2-carbaldossima

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