79100-16-6

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 65057-97-8 tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal 
• 134-20-3 2-carbomethoxyaniline 
• 10333-67-2 methyl 2-(1H-pyrrol-1-yl)benzoate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1095362-17-6 5-(3,4-dimethoxybenzyl)-4,5-dihydro-6H-pyrrolo[1,2-a][1,4]benzodiazepin-6-one 
• 1095362-30-3 5-(3,4-dimethoxybenzyl)-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine 
• 1095362-06-3 C₂₂H₂₄N₂O₄ 
• 39243-92-0 4,5-diidro-6H-pirrolo<1,2-a><1,4>benzodiazepina 
• 92508-14-0 1-(2-metossicarbonilfenil)pirrolo-2-carbaldossima 
• 101130-76-1 4-hydroxy-4H,6H-pyrrolo<1,2-a><4,1>benzoxazepine 
• 79100-19-9 6-oxo-4H-pyrrolo<1,2-a><4,1>benzoxazepine 
• 79100-17-7 N-(2-hydroxymethylphenyl)-2-hydroxymethylpyrrole 

Relevant academic research and scientific papers

MODULAR SYNTHESES OF DISCOIPYRROLE TYPE ALKALOIDS AND ANALOGUES

The present invention relates to methods for preparing a variety of discoipyrrole compounds and analogues using an oxidative cyclisation reaction as one of the steps. The present invention also relates to novel discoipyrrole analogues, pharmaceutical comp

Modular Total Syntheses of the Alkaloids Discoipyrroles A and B, Potent Inhibitors of the DDR2 Signaling Pathway

(Chemical Equation Presented). The title natural product 1 has been synthesized by treating the 1,2,3,5-tetrasubstituted pyrrole 23 with oxoperoxymolybdenum(pyridine) (hexamethylphosphoric triamide) (MoOPH). Compound 23 was itself prepared in seven steps

New method of synthesis of 5,6-dihydro-4H-pyrrolo[1,2-a]-[1,4] benzodiazepines

2,5-Dimethoxy-2-(dimethoxymethyl)tetrahydrofuran 1 reacted with anthranilic acid alkyl esters 2 in boiling acetic acid to give 2-(2-formylpyrrol-1-yl) benzoic acid esters 3. The reductive amination of 3 with primary arylalkylamines 4 led to 2-{2-[(arylalkylamino)methyl]pyrrol-1-yl}-benzoic acids esters 5. Heating of the aminoesters 5 in xylene under reflux resulted in 5-(arylalkyl)-4,5-dihydro-6H-pyrrolo[1,2-a][1,4]benzodiazepin-6-ones 7. Lactams 7 were reduced by lithium aluminum hydride in toluene and and ether solutions to give 5-(arylalkyl)-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines 8. The solid products 8 were recrystallized and the liquid ones were transformed into their salts with oxalic acid. The Japan Institute of Heterocyclic Chemistry.

Heterocyclic Systems. II. Synthesis of 4H,6H-Pyrrolobenzoxazepine

The reduction of 1-(2-methoxycarbonylphenyl)pyrrole-2-carboxaldehyde by lithium aluminum hydride led to 1-(2-hydroxymethylphenyl)-2-hydroxymethylpyrrole, which was in turn transformed into 4H,6H-pyrrolobenzoxazepine through intramolecular dehy