2-(diethylamino)-1-phenylethanol

Base Information

• Chemical Name: 2-(diethylamino)-1-phenylethanol
• CAS No.: 4249-64-3
• Molecular Formula: C12H19 N O
• Molecular Weight: 193.289
• Mol file: 4249-64-3.mol

Synonyms:Benzylalcohol, a-[(diethylamino)methyl]-(6CI,7CI,8CI); NSC 11018; NSC 23631

Chemical Property of 2-(diethylamino)-1-phenylethanol

Chemical Property:

• Vapor Pressure: 0.000485mmHg at 25°C
• Boiling Point: 300.9°Cat760mmHg
• Flash Point: 107.2°C
• Density: 0.997g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(diethylamino)-1-phenylethanol

There total 17 articles about 2-(diethylamino)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

styrene oxide (96-09-3) + diethylamine (109-89-7) → 2-diethylamino-1-phenyl-1-ethanol (4249-64-3)

Guidance literature:

With lithium perchlorate; at 20 ℃; for 1h;

DOI:10.1139/v05-062

Reference yield: 78.0%

→ 2-diethylamino-1-phenyl-1-ethanol (4249-64-3)

Guidance literature:

With dibromohydantoin; In water; acetone; at 20 ℃; for 0.5h;

In water; acetone; at 20 ℃; for 4h;

Reference yield:

styrene oxide (96-09-3) + 1-diethylamino-2-propanol (4402-32-8) → 2-diethylamino-1-phenyl-1-ethanol (4249-64-3) + methyloxirane (75-56-9,16033-71-9)

Guidance literature:

at 150 ℃; for 12h; Product distribution; Mechanism; exchange reaction;

DOI:10.1007/BF00963418

upstream raw materials:

styrene oxide

diethylamine

N,N-diethylphenacylamine

N,N-diethyl-2-oxo-2-phenylacetamide

Downstream raw materials:

4-nitro-benzoic acid-(2-diethylamino-1-phenyl-ethyl ester)

α-Diaethylaminomethylbenzylbenzoat

N,N-Diaethyl-2-brom-2-phenyl-aethylamin

β-Diaethylamino-α-fluoro-aethylbenzol

Refernces

• 1、 -. "Process for preparing beta-aminoalcohol from terminal olefin". Paragraph 0031-0033; 0043. . Retrieved 2020/06/17.
• 2、 Karimi, Meghdad,Hajiashrafi, Taraneh,Heydari, Akbar,Azhdari Tehrani, Alireza. "Terbium–organic framework as heterogeneous Lewis acid catalyst for β-aminoalcohol synthesis: Efficient, reusable and green catalytic method". . . Retrieved 2017/10/03.