4402-32-8

Basic information

• Product Name: 1-DIETHYLAMINO-2-PROPANOL
• Synonyms: 1-(diethylamino)-2-propano;1-DIETHYLAMINO-2-PROPANOL;1-diethylaminopropan-2-ol;1-Diethylamino-2-propanol,97%;1-DiethylaMino-2-propanol, 97% 100ML;NSC 6304;N,N-Diethylisopropanolamine;N,N-Diethyl-2-hydroxypropylamine
• CAS NO: 4402-32-8
• Molecular Formula: C₇H₁₇NO
• Molecular Weight: 131.22
• EINECS: 224-537-7
• Mol File: 4402-32-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 13.5 °C(lit.)
• Boiling Point: 55-59 °C13 mm Hg(lit.)
• Flash Point: 92 °F
• Appearance: /
• Density: 0.889 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.04mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Storage Temp.: Flammables area
• PKA: 14.81±0.20(Predicted)
• BRN: 969221
• CAS DataBase Reference: 1-DIETHYLAMINO-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-DIETHYLAMINO-2-PROPANOL(4402-32-8)
• EPA Substance Registry System: 1-DIETHYLAMINO-2-PROPANOL(4402-32-8)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 24/25
• RIDADR: UN 1987 3/PG 3
• WGK Germany: 3
• F: 9-23
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4402-32-8(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly yellow liquid

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 739, 1989 DOI: 10.1016/S0040-4039(01)80297-5

Flammability and Explosibility

Flammable

InChI:InChI=1/C7H17NO/c1-4-8(5-2)6-7(3)9/h7,9H,4-6H2,1-3H3/t7-/m0/s1

Upstream product

• 1620-14-0 1-(diethylamino)propan-2-one 
• 109-89-7 diethylamine 
• 127-00-4 1-Chloro-2-propanol 
• 75-56-9 methyloxirane 
• 24294-42-6 N-(2-hydroxypropyl)-N,N-diethylamine N-oxide 
• 125582-78-7 C₁₀H₂₅NPb 
• 124-38-9 carbon dioxide 
• 5666-17-1 N,N-diethylallylamine 
• 7664-93-9 sulfuric acid 
• 78679-31-9 1-diethylamino-2-trimethylsiloxypropane 
• 19686-73-8 1-bromo-2-propanol 

Downstream Products

• 100861-95-8 (+)-phenylcarbamic acid-(2-diethylamino-1-methyl-ethyl ester) 
• 100861-95-8 (-)-phenylcarbamic acid-(2-diethylamino-1-methyl-ethyl ester) 
• 111030-10-5 4-methoxy-benzoic acid-(β-diethylamino-isopropyl ester) 
• 109-89-7 diethylamine 
• 108838-18-2 2-methoxy-benzoic acid-(β-diethylamino-isopropyl ester) 
• 102702-56-7 phthalic acid bis-(β-diethylamino-isopropyl ester) 
• 101450-70-8 3,4-dimethoxy-benzoic acid-(β-diethylamino-isopropyl ester) 
• 102458-72-0 2-benzoyloxy-1-diethylamino-propane 
• 101745-21-5 2-phenyl-butyric acid-(β-diethylamino-isopropyl ester) 
• 761-21-7 1-diethylamino-2-chloropropane 
• 18262-04-9 2-(diethylamino)-1-methylethyl methacrylate 
• 4195-36-2 (4-Chloro-phenoxy)-acetic acid 2-diethylamino-1-methyl-ethyl ester 
• 21500-78-7 α-methylprocaine 
• 14377-39-0 4-tert.-Butyl-benzoesaeure-<1-diethylamino-propyl-(2)-ester> 

Relevant articles and documents

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Tetragonal versus hexagonal: Structure-dependent catalytic activity of Co/Zn bimetallic metal-organic frameworks

Tetragonal and hexagonal phases of monometallic Zn and bimetallic Co/Zn metal-organic frameworks (MOFs), with secondary building units (SBUs) containing a M3O (M = metal) cluster, were synthesized from identical constituents using a benzenetricarboxylate (BTC3-) linker that forms decorated 3,6- and 3,5-connected networks, respectively. There exist subtle differences between the SBUs; one of the metal atoms in the M3O cluster in the tetragonal phase has one dissociable DMF solvent molecule while that in the hexagonal phase has three. Connectivities between the SBUs form one-dimensional channels in both MOFs. These MOFs catalyze the chemoselective addition of amines to epoxides, giving exclusively β-hydroxyamine under heterogeneous conditions. A ring-opening reaction of a symmetrical epoxide showed that the hexagonal phase diastereoselectively yields trans-alcohol, exhibiting an exquisite model for structure-dependent activity.

The reaction of carbonyldiimidazole with alcohols to form carbamates and N-alkylimidazoles

The reactions of non-benzylic primary and secondary aliphatic alcohols with carbonyldiimidazole (CDI) afford the corresponding carbamates but not N-alkylimidazoles. For benzylic primary alcohols, formation of N-alkylimidazoles proceeds reasonably at 170 °C in several different solvents and occurs by way of the initially formed carbamate. However, under these rather forcing conditions, or even at lower reaction temperatures, elimination is a significant side reaction for benzylic secondary alcohols with β-hydrogen atoms. With one exception, reactions of six N,N-disubstituted β-aminoalcohols with CDI to form N-alkylimidazoles proceed under relatively mild conditions and may occur by way of an aziridinium intermediate.