Pipramadol

Base Information

Chemical Name:Pipramadol
CAS No.:55313-67-2
Molecular Formula:C₂₃H₃₅ClN₂O₂
Molecular Weight:406.996
Hs Code.:
UNII:24HB54N554,6QR1645G9S,5CYZ4W1X8K
DSSTox Substance ID:DTXSID40866480
Wikidata:Q106643157
NCI Thesaurus Code:C66406
ChEMBL ID:CHEMBL146727
Mol file:55313-67-2.mol

Synonyms:Pipramadol;Pipramadol [INN];Pipramadol, (-)-;55313-67-2;5CYZ4W1X8K;Pipramadol, (+)-;UNII-5CYZ4W1X8K;UNII-6QR1645G9S;6QR1645G9S;24HB54N554;FQ-27-096;2-[1-[2-(2-chlorophenyl)ethyl]-4-hydroxypiperidin-4-yl]-N-cyclohexyl-N-methylpropanamide;83605-14-5;4-Piperidineacetamide, 1-(2-(2-chlorophenyl)ethyl)-N-cyclohexyl-4-hydroxy-N,alpha-dimethyl-, (-)-;83605-12-3;2-{1-[2-(2-CHLOROPHENYL)ETHYL]-4-HYDROXYPIPERIDIN-4-YL}-N-CYCLOHEXYL-N-METHYLPROPANAMIDE;C23H35ClN2O2;CHEMBL146727;SCHEMBL2111004;UNII-24HB54N554;DTXSID40866480;C23-H35-Cl-N2-O2;(+-)-1-(o-Chlorophenethyl)-N-cyclohexyl-4-hydroxy-N,alpha-dimethyl-4-piperidineacetamide;(- )-1-(o-Chlorophenethyl)-N-cyclohexyl-4-hydroxy-N,alpha-dimethyl-4-piperidineacetamide;(+/-)-1-(O-CHLOROPHENETHYL)-N-CYCLOHEXYL-4-HYDROXY-N,.ALPHA.-DIMETHYL-4-PIPERIDINEACETAMIDE;4-PIPERIDINEACETAMIDE, 1-(2-(2-CHLOROPHENYL)ETHYL)-N-CYCLOHEXYL-4-HYDROXY-N,.ALPHA.-DIMETHYL-, (+)-;4-PIPERIDINEACETAMIDE, 1-(2-(2-CHLOROPHENYL)ETHYL)-N-CYCLOHEXYL-4-HYDROXY-N,.ALPHA.-DIMETHYL-, (-)-;4-Piperidineacetamide, 1-(2-(2-chlorophenyl)ethyl)-N-cyclohexyl-4-hydroxy-N,alpha-dimethyl-, (+)-

Suppliers and Price of Pipramadol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
PIPRAMADOL 95.00%
5MG
$ 503.84

Total 3 raw suppliers

Chemical Property of Pipramadol

Chemical Property:

Vapor Pressure:2.58E-13mmHg at 25°C
Boiling Point:558.6°C at 760 mmHg
Flash Point:291.6°C
PSA：43.78000
Density:1.16g/cm³
LogP:4.07450
XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:406.2387061
Heavy Atom Count:28
Complexity:501

Purity/Quality:

99% ^*data from raw suppliers

PIPRAMADOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)N(C)C1CCCCC1)C2(CCN(CC2)CCC3=CC=CC=C3Cl)O

Technology Process of Pipramadol

There total 11 articles about Pipramadol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 55313-67-2,83605-12-3,83605-14-5
2-<1-(2-chlorophenethyl)-4-hydroxy-4-piperidinyl>-N-cyclohexyl-N-methylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98.7 percent / acetic acid / 6 h / 60 °C

2: Na, propanol / 1 h / Heating

3: conc. HCl / propan-2-ol; H₂O / 6 h / 20 - 130 °C

4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

With hydrogenchloride; propan-1-ol; sodium; acetic acid; lithium diisopropyl amide; In water; isopropyl alcohol;
DOI:10.1021/jm00355a010

Reference yield:

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 55313-67-2,83605-12-3,83605-14-5
(-)-2-<1-(2-chlorophenethyl)-4-hydroxy-4-piperidinyl>-N-cyclohexyl-N-methylpropionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 98.7 percent / acetic acid / 6 h / 60 °C

2: Na, propanol / 1 h / Heating

3: conc. HCl / propan-2-ol; H₂O / 6 h / 20 - 130 °C

4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

6: 1.) Mg, EtBr / 1.) THF, from 20 to 25 deg C, 1 h, 2.) THF, 65 deg C, 3 h

With hydrogenchloride; propan-1-ol; ethidium Bromide; sodium; magnesium; acetic acid; lithium diisopropyl amide; In water; isopropyl alcohol;
DOI:10.1021/jm00355a010

Reference yield:

: 100-60-7
N-methylcyclohexylamine

: 55313-67-2,83605-12-3,83605-14-5
2-<1-(2-chlorophenethyl)-4-hydroxy-4-piperidinyl>-N-cyclohexyl-N-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 1 h / 20 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

With triethylamine; lithium diisopropyl amide; In chloroform;
DOI:10.1021/jm00355a010