Technology Process of N,N,3-trimethyl-3-phenyloxirane-2-carboxamide
There total 4 articles about N,N,3-trimethyl-3-phenyloxirane-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2-Ethylhexanoic acid; C36H40F6MnN6O6S2; dihydrogen peroxide;
In
acetonitrile;
at -40 ℃;
for 1h;
enantioselective reaction;
DOI:10.1021/acs.orglett.9b00729
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / water; ethanol
3.1: 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline / dichloromethane / 0.5 h / 20 °C
3.2: 5 h / Reflux
4.1: C36H40F6MnN6O6S2; 2-Ethylhexanoic acid; dihydrogen peroxide / acetonitrile / 1 h / -40 °C
With
2-Ethylhexanoic acid; C36H40F6MnN6O6S2; dihydrogen peroxide; sodium hydride; sodium hydroxide; 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; mineral oil;
DOI:10.1021/acs.orglett.9b00729
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; ethanol
2.1: 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline / dichloromethane / 0.5 h / 20 °C
2.2: 5 h / Reflux
3.1: C36H40F6MnN6O6S2; 2-Ethylhexanoic acid; dihydrogen peroxide / acetonitrile / 1 h / -40 °C
With
2-Ethylhexanoic acid; C36H40F6MnN6O6S2; dihydrogen peroxide; sodium hydroxide; 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline;
In
ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.orglett.9b00729
