2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde

Base Information

Chemical Name:2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde
CAS No.:113984-72-8
Molecular Formula:C21H17FO3
Molecular Weight:336.363
Hs Code.:
DSSTox Substance ID:DTXSID201264097
Mol file:113984-72-8.mol

Synonyms:DTXSID201264097;113984-72-8;2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde

Suppliers and Price of 2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:336.11617256
Heavy Atom Count:25
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC(=C(C(=C2)OCC3=CC=CC=C3)F)C=O

Technology Process of 2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde

There total 5 articles about 2-Fluoro-3,5-bis(phenylmethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 100-39-0
benzyl bromide

: 113984-64-8
3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzaldehyde

: 113984-72-8
3,5-Bis-benzyloxy-2-fluoro-benzaldehyde

Guidance literature:: With potassium fluoride; In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1248/cpb.38.2939

Reference yield:

: 113984-68-2
4-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene

: 113984-72-8
3,5-Bis-benzyloxy-2-fluoro-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

2: 95 percent / imidazole / dimethylformamide / 15 h / 25 °C

3: 1.) sec-BuLi / 1.) THF, -78 deg C, 1 h

4: 92 percent / KF / dimethylformamide / 2 h / 25 °C

With 1H-imidazole; potassium fluoride; Trimethyl borate; dihydrogen peroxide; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95560-6

Reference yield:

: 113984-74-0
4-(tert-butyldimethylsilyloxy)-1-fluoro-2-hydroxybenzene

: 113984-72-8
3,5-Bis-benzyloxy-2-fluoro-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 15 h / 25 °C

2: 1.) sec-BuLi / 1.) THF, -78 deg C, 1 h

3: 92 percent / KF / dimethylformamide / 2 h / 25 °C

With 1H-imidazole; potassium fluoride; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95560-6