Benzoic acid, 2-fluoro-4-hydroxy-, 1-methylheptyl ester, (R)-

Base Information

• Chemical Name: Benzoic acid, 2-fluoro-4-hydroxy-, 1-methylheptyl ester, (R)-
• CAS No.: 114045-95-3
• Molecular Formula: C15H21FO3
• Molecular Weight: 268.328
• Mol file: 114045-95-3.mol

Synonyms:

Chemical Property of Benzoic acid, 2-fluoro-4-hydroxy-, 1-methylheptyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-fluoro-4-hydroxy-, 1-methylheptyl ester, (R)-

There total 7 articles about Benzoic acid, 2-fluoro-4-hydroxy-, 1-methylheptyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(R)-(-)-1-methylheptyl 4-benzyloxy-2-fluorobenzoate (239803-48-6) → (R)-(-)-1-methylheptyl 4-hydroxy-2-fluorobenzoate (114045-95-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1039/b009426i

Reference yield:

1'-methylheptyl 2-fluoro-4-benzyloxy-benzoate (172210-48-9) → (R)-(-)-1-methylheptyl 4-hydroxy-2-fluorobenzoate (114045-95-3)

Guidance literature:

palladium-carbon catalyst; In ethyl acetate;

Reference yield:

3-fluorophenol (372-20-3) → (R)-(-)-1-methylheptyl 4-hydroxy-2-fluorobenzoate (114045-95-3)

Guidance literature:

Multi-step reaction with 6 steps

1: Br₂; AcOH

2: 96 percent / K₂CO₃ / butan-2-one

3: 71 percent / 1-methyl-pyrrolidin-2-one / 24 h / Heating

4: 58 percent / aq. NaOH / 60 h / Heating

5: 69 percent / DEAD; PPh₃ / tetrahydrofuran

6: 76 percent / H₂ / 10 percent Pd/C / ethyl acetate

With sodium hydroxide; hydrogen; bromine; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl acetate; butanone;

DOI:10.1039/b009426i

upstream raw materials:

(R)-(-)-1-methylheptyl 4-benzyloxy-2-fluorobenzoate

3-fluorophenol

4-bromo-3-fluorophenol

4-Benzyloxy-2-fluoro-benzoic Acid

Downstream raw materials:

(R)-(-)-4-(1-methylheptyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

Refernces

• 1、 -. "Halogenen-substituted phenyl benzyl ether derivatives, liquid crystal compositions containing them and optical switching element". . . Retrieved 2008/06/13.