4-Benzyloxy-2-fluorobenzoic ac

Base Information

• Chemical Name: 4-Benzyloxy-2-fluorobenzoic ac
• CAS No.: 114045-96-4
• Molecular Formula: C14H11FO3
• Molecular Weight: 246.238
• Hs Code.: 2918990090
• Mol file: 114045-96-4.mol

Synonyms:4-Benzyloxy-2-fluorobenzoic acid;2-fluoro-4-phenylmethoxybenzoic acid;

Chemical Property of 4-Benzyloxy-2-fluorobenzoic ac

Chemical Property:

• Melting Point: 165-168℃
• Boiling Point: 380.0±27.0 °C(Predicted)
• PKA: 3.53±0.10(Predicted)
• PSA: 46.53000
• Density: 1.289±0.06 g/cm3(Predicted)
• LogP: 3.10290
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-(Benzyloxy)-2-fluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 4-Benzyloxy-2-fluorobenzoic ac

There total 15 articles about 4-Benzyloxy-2-fluorobenzoic ac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-fluoro-4-phenylmethoxybenzonitrile (185836-35-5) → 4-Benzyloxy-2-fluoro-benzoic Acid (114045-96-4)

Guidance literature:

Reference yield: 78.0%

→ 4-Benzyloxy-2-fluoro-benzoic Acid (114045-96-4)

Guidance literature:

Reference yield: 52.0%

benzyl bromide (100-39-0) + 2-fluoro-4-hydroxybenzoic acid (65145-13-3) → 4-Benzyloxy-2-fluoro-benzoic Acid (114045-96-4)

Guidance literature:

benzyl bromide; 2-fluoro-4-hydroxybenzoic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h; Inert atmosphere;

With lithium hydroxide monohydrate; In tetrahydrofuran; water; for 8h; Reflux; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b01201

upstream raw materials:

2-fluoro-4-phenylmethoxybenzonitrile

carbon dioxide

4-(benzyloxy)-1-bromo-2-fluorobenzene

benzyl bromide

Downstream raw materials:

1'-methylheptyl 2-fluoro-4-benzyloxy-benzoate

Refernces

• 1、 -. "DIPHENYL SUBSTITUTED ALKANES". . . Retrieved 2009/01/23.
• 2、 -. "Heteroaromatic quinoline compounds". Page/Page column 36. . Retrieved 2008/06/13.