Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite)

Base Information

Chemical Name:Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite)
CAS No.:114071-79-3
Molecular Formula:C₂₈H₄₁F₃N₅O₆PSi₂
Molecular Weight:687.803
Hs Code.:
Mol file:114071-79-3.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite)

Chemical Property:

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Technology Process of Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite)

There total 1 articles about Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101803-22-9
bis((2,2,2)-trifluoroethyl)trimethylsilylphosphite

: 51549-39-4
N⁶-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine

: 114071-79-3
C₂₈H₄₁F₃N₅O₆PSi₂

Guidance literature:: DOI:10.1016/S0040-4039(00)95534-5

Reference yield:

: 114071-79-3
C₂₈H₄₁F₃N₅O₆PSi₂

: 114071-83-9
Phosphorochloridic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-ethyl ester

Guidance literature:: With sulfuryl dichloride; In dichloromethane; 1.) 0 deg C, 2.) 30 min, room temperature;
DOI:10.1016/S0040-4039(00)95534-5

Reference yield:

: 114071-79-3
C₂₈H₄₁F₃N₅O₆PSi₂

: 114071-87-3
Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl chloride / CH₂Cl₂ / 1.) 0 deg C, 2.) 30 min, room temperature

2: triethylamine / CH₂Cl₂ / 1 h

With sulfuryl dichloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)95534-5