Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

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Chemical Name:Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester
CAS No.:114071-87-3
Molecular Formula:C₄₉H₅₂F₃N₁₀O₁₁PSi
Molecular Weight:1073.07
Hs Code.:

Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

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Suppliers and Price of Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

There total 3 articles about Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114071-79-3
C₂₈H₄₁F₃N₅O₆PSi₂

: 114071-87-3
Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl chloride / CH₂Cl₂ / 1.) 0 deg C, 2.) 30 min, room temperature

2: triethylamine / CH₂Cl₂ / 1 h

With sulfuryl dichloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)95534-5

Reference yield:

: 51549-39-4
N⁶-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine

: 114071-87-3
Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

2: sulfuryl chloride / CH₂Cl₂ / 1.) 0 deg C, 2.) 30 min, room temperature

3: triethylamine / CH₂Cl₂ / 1 h

With sulfuryl dichloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)95534-5