2-(DIMETHYLAMINO)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE

Base Information

• Chemical Name: 2-(DIMETHYLAMINO)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE
• CAS No.: 114084-96-7
• Molecular Formula: C₁₅H₁₂F₃N₃
• Molecular Weight: 291.276
• Mol file: 114084-96-7.mol

Synonyms:2-Dimethylamino-6-phenyl-4-trifluoromethyl-nicotinonitrile;

Chemical Property of 2-(DIMETHYLAMINO)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE

Chemical Property:

• PSA: 39.92000
• LogP: 3.70508

Purity/Quality:

2-(Dimethylamino)-6-phenyl-4-(trifluoromethyl)nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(DIMETHYLAMINO)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE

There total 2 articles about 2-(DIMETHYLAMINO)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine (114084-91-2) + dimethyl amine (124-40-3) → 2-(N,N-dimethylamino)-4-trifluoromethyl-6-phenyl-3-cyanopyridine (114084-96-7)

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1007/BF00475366

Reference yield:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-44-2) → 2-(N,N-dimethylamino)-4-trifluoromethyl-6-phenyl-3-cyanopyridine (114084-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / POCl₃, DMF / 8 h / 130 °C

2: 74 percent / ethanol / 1 h / Heating

With N,N-dimethyl-formamide; trichlorophosphate; In ethanol;

DOI:10.1007/BF00475366

upstream raw materials:

4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine

dimethyl amine

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile