4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane

Base Information

Chemical Name:4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane
CAS No.:114185-01-2
Molecular Formula:C25H26O4
Molecular Weight:390.479
Hs Code.:
DSSTox Substance ID:DTXSID90551637
Mol file:114185-01-2.mol

Synonyms:114185-01-2;4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane;DTXSID90551637

Suppliers and Price of 4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:390.18310931
Heavy Atom Count:29
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(O1)C2=CC=CC=C2)C(COCC3=CC=CC=C3)OCC4=CC=CC=C4

Technology Process of 4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane

There total 7 articles about 4-[1,2-Bis(benzyloxy)ethyl]-2-phenyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 100-52-7
benzaldehyde

: 114185-00-1
(2R,3S)-3,4-Bis-benzyloxy-butane-1,2-diol

: 114185-01-2
(2R,3S)-3,4-di-O-benzyl-1,2-O-benzylidenebutane-1,2,3,4-tetrol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 20h; Heating;
DOI:10.1021/jo00246a037

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 114185-01-2
(2R,3S)-3,4-di-O-benzyl-1,2-O-benzylidenebutane-1,2,3,4-tetrol

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dimethylformamide / 120 h / Ambient temperature

2: 1.) 30percent H₂O₂, K₂CO₃ / 1.) water, RT, overnight, 2.) acetonitrile, reflux, 20 h

3: 80.3 percent / lithium aluminum hydride / tetrahydrofuran / a) RT, 18 h, b) reflux, 1 h

4: 1.) NaH / 1.) DMF, RT, 20 min, 2.) RT, overnight

With lithium aluminium tetrahydride; dihydrogen peroxide; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00246a037

Reference yield:

: 100-39-0
benzyl bromide

: 114185-01-2
(2R,3S)-3,4-di-O-benzyl-1,2-O-benzylidenebutane-1,2,3,4-tetrol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 25 min, 2.) 1h

2: 92.3 percent / conc. HCl, amberlite CG-120 / aq. ethanol; H₂O / Ambient temperature

3: 89.2 percent / p-toluenesulfonic acid / benzene / 20 h / Heating

With hydrogenchloride; Amberlite CG-120; sodium hydride; toluene-4-sulfonic acid; In ethanol; water; benzene;
DOI:10.1021/jo00246a037