2-CHLORO-N-CYCLOHEXYL-ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-CYCLOHEXYL-ACETAMIDE
• CAS No.: 23605-23-4
• Molecular Formula: C8H14ClNO
• Molecular Weight: 175.658
• Hs Code.: 2924299090
• Mol file: 23605-23-4.mol

Synonyms:2-Chloro-N-cyclohexylacetamide;N-(Chloroacetyl)cyclohexylamine;N-Cyclohexyl-2-chloroacetamide;N-Cyclohexyl-a-chloroacetamide;N-Cyclohexylchloroacetamide;NSC 8278;a-Chloro-N-cyclohexylacetamide;

Chemical Property of 2-CHLORO-N-CYCLOHEXYL-ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.000216mmHg at 25°C
• Melting Point: 109-111 °C
• Refractive Index: 1.484
• Boiling Point: 326.4 °C at 760 mmHg
• PKA: 13.97±0.20(Predicted)
• Flash Point: 151.2 °C
• PSA: 29.10000
• Density: 1.1 g/cm³
• LogP: 2.06500
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-N-cyclohexylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-CYCLOHEXYL-ACETAMIDE

There total 12 articles about 2-CHLORO-N-CYCLOHEXYL-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexylamine (108-91-8,157973-60-9) + chloroacetyl chloride (79-04-9) → 2-Chloro-N-cyclohexylacetamide (23605-23-4)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.tetlet.2003.09.216

Reference yield: 100.0%

→ 2-Chloro-N-cyclohexylacetamide (23605-23-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 97.0%

Chloroiodomethane (593-71-5) + Cyclohexyl isocyanate (3173-53-3) → 2-Chloro-N-cyclohexylacetamide (23605-23-4)

Guidance literature:

With methyllithium lithium bromide; In diethyl ether; at -78 ℃;

DOI:10.1039/c3cc44255a

upstream raw materials:

dichlorodiacetamide

cyclohexylamine

chloroacetic acid

chloroacetyl chloride

Downstream raw materials:

(8-amino-[2]naphthyloxy)-acetic acid cyclohexylamide

disulfanediyldi-acetic acid bis-cyclohexylamide

N-cyclohexyl-2-iodoacetamide

N,N-dimethyl-glycine cyclohexylamide