Isoxazolidine, 5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(1H-imidazol-1-ylmeth yl)-2-methyl-, trans-

Base Information

• Chemical Name: Isoxazolidine, 5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(1H-imidazol-1-ylmeth yl)-2-methyl-, trans-
• CAS No.: 114372-39-3
• Molecular Formula: C₂₁H₂₁Cl₂N₃O₂
• Molecular Weight: 418.323
• Mol file: 114372-39-3.mol

Synonyms:

Chemical Property of Isoxazolidine, 5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(1H-imidazol-1-ylmeth yl)-2-methyl-, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoxazolidine, 5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(1H-imidazol-1-ylmeth yl)-2-methyl-, trans-

There total 5 articles about Isoxazolidine, 5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(1H-imidazol-1-ylmeth yl)-2-methyl-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

1-allyloxy-4-chlorobenzene (13997-70-1) + 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide (119393-45-2,113944-25-5) → trans-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine (114372-39-3) + cis-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine (114372-38-2)

Guidance literature:

In toluene; for 46h; Heating;

DOI:10.1002/hlca.19880710406

Reference yield:

1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one (24155-32-6) → trans-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine (114372-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / AcONa / ethanol / 48 h / Ambient temperature

2: 12.2 percent / toluene / 46 h / Heating

With sodium acetate; In ethanol; toluene;

DOI:10.1002/hlca.19880710406

Reference yield:

1-allyloxy-4-chlorobenzene (13997-70-1) + (E)-1-(4-chlorophenyl)-N-methyl-2-(1H-azol-1-yl)ethanimine N-oxide (113944-25-5,119393-45-2) → trans-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine (114372-39-3) + cis-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine (114372-38-2)

Guidance literature:

In toluene; Yield given. Yields of byproduct given; Heating;

upstream raw materials:

1-allyloxy-4-chlorobenzene

(E)-1-(4-chlorophenyl)-N-methyl-2-(1H-azol-1-yl)ethanimine N-oxide

1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide

N-methylhydroxyamine hydrochloride