4,7-DIHYDROXY-3-PHENYLCOUMARIN

Base Information

• Chemical Name: 4,7-DIHYDROXY-3-PHENYLCOUMARIN
• CAS No.: 19225-17-3
• Molecular Formula: C15H10O4
• Molecular Weight: 254.2375
• Hs Code.: 2932209090
• Mol file: 19225-17-3.mol

Synonyms:Coumarin,4,7-dihydroxy-3-phenyl- (6CI,7CI,8CI);3-Phenyl-4,7-dihydroxycoumarin;4,7-Dihydroxy-3-phenylcoumarin;

Chemical Property of 4,7-DIHYDROXY-3-PHENYLCOUMARIN

Chemical Property:

• Vapor Pressure: 6.55E-10mmHg at 25°C
• Refractive Index: 1.712
• Boiling Point: 511.48 °C at 760 mmHg
• Flash Point: 200.652 °C
• PSA: 70.67000
• Density: 1.472g/cm³
• LogP: 2.87120

Purity/Quality:

99% ^*data from raw suppliers

4,7-Dihydroxy-3-phenyl-2H-chromen-2-one 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-DIHYDROXY-3-PHENYLCOUMARIN

There total 6 articles about 4,7-DIHYDROXY-3-PHENYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4,7-diacetoxy-3-phenylcoumarin (95316-40-8) → 4,7-dihydroxy-3-phenylcoumarin (19225-17-3)

Guidance literature:

In tetrahydrofuran; butan-1-ol; at 42 - 45 ℃; porcine pancreas type II lipase;

DOI:10.1039/c39930000027

Reference yield:

3-(2,4-dimethoxy-phenyl)-3-oxo-2-phenyl-propionitrile (101442-26-6) → 4,7-dihydroxy-3-phenylcoumarin (19225-17-3)

Guidance literature:

With pyridine hydrochloride; anschliessend erhitzen mit wss. Salzsaeure;

DOI:10.1246/bcsj.32.11

Reference yield:

4-hydroxy-7-methoxy-3-phenylcoumarin (2555-24-0) → 4,7-dihydroxy-3-phenylcoumarin (19225-17-3)

Guidance literature:

With hydrogen iodide; acetic anhydride; acetic acid;

DOI:10.1039/jr9480000174

upstream raw materials:

4-hydroxy-7-methoxy-3-phenylcoumarin

3-(2,4-dimethoxy-phenyl)-3-oxo-2-phenyl-propionitrile

diethyl 2-phenylmalonate

recorcinol

Downstream raw materials:

4,7-dihydroxy-8-methyl-3-phenyl-2H-chromen-2-one

7-hydroxy-4-(2-morpholin-4-yl-ethoxy)-3-phenyl-chromen-2-one

4,7-diacetoxy-3-phenylcoumarin

Refernces

• 1、 DESCHAMPS-VALLET. "ON A MODE OF DIFFERENTIATION OF 4,5AND 4,7-DIHYDROXYCOUMARINS IN". . p. 1181 - 1183. Retrieved 2007/10/08.