4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9&

Base Information

• Chemical Name: 4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9&
• CAS No.: 2555-24-0
• Molecular Formula: C16H12 O4
• Molecular Weight: 268.269
• Mol file: 2555-24-0.mol

Synonyms:Coumarin,4-hydroxy-7-methoxy-3-phenyl- (7CI,8CI); 3-Phenyl-4-hydroxy-7-methoxycoumarin;4-Hydroxy-7-methoxy-3-phenylcoumarin

Chemical Property of 4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9&

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 204-206 °C(lit.)
• Refractive Index: 1.652
• Boiling Point: 476.479°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 182.187°C
• PSA: 59.67000
• Density: 1.353g/cm³
• LogP: 3.17420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9&

There total 13 articles about 4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

O-methylresorcine (150-19-6) + dimethyl 2-phenylmalonate (37434-59-6) → 4-hydroxy-7-methoxy-3-phenylcoumarin (2555-24-0)

Guidance literature:

O-methylresorcine; dimethyl 2-phenylmalonate; In diphenylether; at 200 - 250 ℃; for 3h;

In diphenylether; for 2h; Heating;

DOI:10.3390/molecules17089245

Reference yield: 85.0%

C17H16O5 (1353024-72-2) → 4-hydroxy-7-methoxy-3-phenylcoumarin (2555-24-0)

Guidance literature:

With pyridine; potassium hydroxide;

DOI:10.1080/00397910903222082

Reference yield: 82.0%

4-hydroxy-7-methoxycoumarine (17575-15-4) + triphenylbismuth(V) diacetate (28899-97-0,7239-60-3) → 4-hydroxy-7-methoxy-3-phenylcoumarin (2555-24-0)

Guidance literature:

In dichloromethane; for 43h; Heating; dark;

DOI:10.1016/S0040-4020(01)89826-4

upstream raw materials:

O-methylresorcine

diethyl 2-phenylmalonate

1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone

Diethyl carbonate

Downstream raw materials:

4,7-dimethoxy-3-phenyl-coumarin

4,7-dihydroxy-3-phenylcoumarin

4-acetoxy-7-methoxy-3-phenyl-coumarin

ethyl 2-(7-methoxy-3-phenylcoumarin-4-yloxy)acetate