2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol

Base Information

Chemical Name:2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol
CAS No.:6291-50-5
Molecular Formula:C₉H₈N₂O₆
Molecular Weight:240.172
Hs Code.:
NSC Number:5145
ChEMBL ID:CHEMBL1797939

Synonyms:2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol;6291-50-5;3-Nitro-4-(2-nitrovinyl)-2-methoxyphenol;3-nitro-4-{2-nitrovinyl}-2-methoxyphenol;NSC5145;CHEMBL1797939;NSC-5145;ANM100460;2-methoxy-3-nitro-4-(2-nitroethenyl)phenol;AE-508/36398056

Suppliers and Price of 2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol

Chemical Property:

Vapor Pressure:2.05E-08mmHg at 25°C
Boiling Point:441.7°Cat760mmHg
Flash Point:220.9°C
Density:1.492g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:240.03823598
Heavy Atom Count:17
Complexity:320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1[N+](=O)[O-])C=C[N+](=O)[O-])O
Isomeric SMILES:COC1=C(C=CC(=C1[N+](=O)[O-])/C=C/[N+](=O)[O-])O

Technology Process of 2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol

There total 5 articles about 2-methoxy-3-nitro-4-[(E)-2-nitroethenyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 75-52-5
nitromethane

: 2450-26-2
2-nitrovanillin

: 6291-50-5
4-hydroxy-3-methoxy-2,β-dinitrostyrene

Guidance literature:: With ammonium acetate; acetic acid; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1002/jhet.2251

Reference yield:

: 881-68-5
vanillin acetate

: 6291-50-5
4-hydroxy-3-methoxy-2-nitro-β-nitrostyrene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) fuming nitric acid, 2.) HCl / 1.) 2 deg C - 6 deg C, 15 min

2: 63 percent / ammonium acetate / acetic acid / 2 h / Heating

With ammonium acetate; hydrogenchloride; nitric acid; In acetic acid;

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 6291-50-5
4-hydroxy-3-methoxy-2,β-dinitrostyrene

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

2: nitric acid / 0.83 h / -20 °C

3: sodium hydroxide / water / 0.5 h / 20 °C

4: ammonium acetate; acetic acid / 2 h / 120 °C / Inert atmosphere

With ammonium acetate; nitric acid; acetic acid; sodium hydroxide; In tetrahydrofuran; water; 4: |Henry Nitro Aldol Condensation;
DOI:10.1002/jhet.2251