3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Base Information

Chemical Name:3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline
CAS No.:115607-60-8
Molecular Formula:C19H18N2O2
Molecular Weight:306.364
Hs Code.:
DSSTox Substance ID:DTXSID70440510
Nikkaji Number:J510.399A
Wikidata:Q82256843
ChEMBL ID:CHEMBL114827
Mol file:115607-60-8.mol

Synonyms:115607-60-8;CHEMBL114827;1-(8-Methoxy-4-(o-tolylamino)quinolin-3-yl)ethanone;3-acetyl-4-(2-methylphenylamino)-8-methoxyquinoline;SCHEMBL9652120;DTXSID70440510;ZLGHFBJWCWKOHS-UHFFFAOYSA-N;BDBM50001236;1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-ethanone;1-[8-methoxy-4-(2-methylanilino)quinolin-3-yl]ethanone;4-[(2-Methylphenyl)amino]-8-methoxy-3-acetylquinoline

Suppliers and Price of 3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:306.136827821
Heavy Atom Count:23
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1NC2=C3C=CC=C(C3=NC=C2C(=O)C)OC

Technology Process of 3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

There total 5 articles about 3-Acetyl-4-(2-methylphenylamino)-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 144-55-8
sodium hydrogencarbonate

: 115607-73-3
3-acetyl-4-chloro-8-methoxyquinoline

: 95-53-4
o-toluidine

: 115607-60-8
3-acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: In 1,4-dioxane; ethanol;

Reference yield: 44.0%

: 115607-73-3
3-acetyl-4-chloro-8-methoxyquinoline

: 95-53-4
o-toluidine

: 115607-60-8
3-acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: In 1,4-dioxane; for 2h; Heating;
DOI:10.1021/jm00096a018

Reference yield:

: 142781-81-5
2-acetyl-3-o-anisidino-acrylic acid ethyl ester

: 115607-60-8
3-acetyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / diphenyl ether / 1 h / Heating

2: POCl₃ / 0.75 h / Heating

3: 44 percent / dioxane / 2 h / Heating

With trichlorophosphate; In 1,4-dioxane; diphenylether;
DOI:10.1021/jm00096a018