2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol

Base Information

• Chemical Name: 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol
• CAS No.: 116052-91-6
• Molecular Formula: C₁₅H₂₇N₅O₃
• Molecular Weight: 325.411
• Mol file: 116052-91-6.mol

Synonyms:2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol

Chemical Property of 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol

There total 1 articles about 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propionylamino]-acetylamino}-acetylamino)-acetic acid; compound with trifluoro-acetic acid → 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol (116052-91-6)

Guidance literature:

With borane-THF; for 31h; Heating;

DOI:10.1021/ja00226a063

Reference yield: 49.0%

p-toluenesulfonyl chloride (98-59-9) + 2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol (116052-91-6) → Toluene-4-sulfonic acid 2-[{2-[{2-[[(S)-3-(4-nitro-phenyl)-2-(toluene-4-sulfonylamino)-propyl]-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-ethyl ester (116052-92-7)

Guidance literature:

With triethylamine; In acetonitrile; for 8h; Ambient temperature;

DOI:10.1021/ja00226a063

Reference yield:

2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol (116052-91-6) → 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane (135825-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / Et₃N / acetonitrile / 8 h / Ambient temperature

2: 79 percent / Cs₂CO₃ / dimethylformamide / 5 h / 60 °C

3: 91 percent / 96percent H₂SO₄, C₆H₅OH / 48 h / 100 °C

With sulfuric acid; caesium carbonate; triethylamine; phenol; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja00226a063

Downstream raw materials:

Toluene-4-sulfonic acid 2-[{2-[{2-[[(S)-3-(4-nitro-phenyl)-2-(toluene-4-sulfonylamino)-propyl]-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

2-(4-Nitro-benzyl)-1,4,7,10-tetrakis-(toluene-4-sulfonyl)-1,4,7,10-tetraaza-cyclododecane