Methyl (benzyloxy)(dimethoxyphosphoryl)acetate

Base Information

• Chemical Name: Methyl (benzyloxy)(dimethoxyphosphoryl)acetate
• CAS No.: 116087-97-9
• Molecular Formula: C12H17O6P
• Molecular Weight: 288.237
• DSSTox Substance ID: DTXSID90557134
• Mol file: 116087-97-9.mol

Synonyms:116087-97-9;Methyl (benzyloxy)(dimethoxyphosphoryl)acetate;DTXSID90557134

Chemical Property of Methyl (benzyloxy)(dimethoxyphosphoryl)acetate

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 288.07627526
• Heavy Atom Count: 19
• Complexity: 318

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(OCC1=CC=CC=C1)P(=O)(OC)OC

Technology Process of Methyl (benzyloxy)(dimethoxyphosphoryl)acetate

There total 2 articles about Methyl (benzyloxy)(dimethoxyphosphoryl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

O-benzyl 2,2,2-trichloroacetimidate (81927-55-1) + (±)-methyl 2-(dimethoxyphosphinyl)-2-hydroxyacetate (78186-91-1) → methyl α-(dimethoxyphosphinyl)glycolate benzyl ether (116087-97-9)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; for 23h; Ambient temperature;

DOI:10.1246/bcsj.61.3356

Reference yield: 64.0%

benzyl bromide (100-39-0) + (±)-methyl 2-(dimethoxyphosphinyl)-2-hydroxyacetate (78186-91-1) → methyl α-(dimethoxyphosphinyl)glycolate benzyl ether (116087-97-9)

Guidance literature:

With silver(l) oxide; In chloroform; Ambient temperature;

Reference yield: 77.0%

(2S,3S,4R,5R)-2,3,4,5,6-pentakis(benzyloxy)hexanal (116087-59-3) + methyl α-(dimethoxyphosphinyl)glycolate benzyl ether (116087-97-9) → (Z)-(4R,5R,6R,7R)-2,4,5,6,7,8-Hexakis-benzyloxy-oct-2-enoic acid methyl ester

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1246/bcsj.61.3356

upstream raw materials:

O-benzyl 2,2,2-trichloroacetimidate

(±)-methyl 2-(dimethoxyphosphinyl)-2-hydroxyacetate

benzyl bromide