78186-91-1

Usage

Uses

Used in Pharmaceutical Industry:
DiMethoxyphosphinylhydroxy Acetic Acid Methyl Ester is used as a pharmaceutical agent for its ability to release iron from the serum iron transport protein, transferrin. This property makes it a potential candidate for the treatment of conditions related to iron deficiency or dysregulation of iron metabolism.
Used in Biochemical Research:
In the field of biochemical research, DiMethoxyphosphinylhydroxy Acetic Acid Methyl Ester can be utilized as a research tool to study the role of iron in various biological processes and the mechanisms of iron transport and regulation. Its ability to affect the interaction between iron and transferrin can provide valuable insights into the molecular basis of iron-related diseases and the development of novel therapeutic strategies.
Used in Diagnostic Applications:
DiMethoxyphosphinylhydroxy Acetic Acid Methyl Ester may also find applications in the development of diagnostic tools and tests for assessing iron levels and transferrin function in patients. By understanding the compound's interaction with transferrin, researchers can potentially create new methods for detecting and monitoring iron-related disorders.

Upstream product

• 67-56-1 methanol 
• 96-36-6 methyl phosphite 
• 87692-15-7 Methyl glyoxalate hydrate 
• 813-78-5 dimethylphosphoric acid 
• 922-68-9 Methyl glyoxylate 
• 868-85-9 Dimethyl phosphite 

Downstream Products

• 116087-97-9 methyl α-(dimethoxyphosphinyl)glycolate benzyl ether 
• 16141-78-9 methyl 2-dimethoxyphosphoryl-2-methoxyacetate 

Relevant academic research and scientific papers

Determination of absolute configuration of the phosphonic acid moiety of fosfazinomycins

Fosfazinomycins A and B produced by Streptomyces lavendofoliae share the same phosphonate moiety with one chiral centre of unknown configuration which was determined by synthesising both enantiomers of 2-hydroxy-2-phosphonoacetic acid methyl ester. A chiral cyclic phosphite was reacted with methyl glyoxylate in a Pudovik reaction to give a pair of diastereomeric α- hydroxyphosphonates, which were separated by HPLC. The configurations at C-2 were assigned on the basis of single crystal X-ray structure analysis. Deprotection of these diastereomers furnished the enantiomeric α-hydroxyphosphonic acids, of which the (S)-configured had the same sign of optical rotation as the phosphonic acid moiety of the two fosfazinomycins.

Neighbouring Phosphonate Group Participation in Carbene Chemistry

Systematic studies of the effect of the neighbouring phosphonate group on the reactivities of carbene showed that the neighbouring phosphonate group exerts prominent effects on both the product distribution and the reaction products; the results are interpreted as indicating the extent of participation, which seems to be sensitive to the carbenic substituents.

A CONVENIENT METHOD FOR THE SYNTHESIS OF Α-KETOESTERS FROM ALDEHYDES

An efficient two step, two carbon homologation of aldehydes to α-ketoesters is described.

NEW ACYL ANION EQUIVALENT. A SHORT ROUTE TO THE ENOL LACTAM INTERMEDIATE IN CYTOCHALASIN SYNTHESIS

The preparation and Emmons-Horner reactions of various α-alkoxyphosphonoacetates were examined.The latter reactions proceeded with considerable stereoselectivity, which allowed the efficient preparation of an intermediate in cytochalasin synthesis.