(4S)-4-[(3aR)-2-Oxo-3-methylene-6-methyl-2,3,3aα,4,7,7aα-hexahydrobenzofuran-5-yl]pentanoic acid methyl ester

Base Information

Chemical Name:(4S)-4-[(3aR)-2-Oxo-3-methylene-6-methyl-2,3,3aα,4,7,7aα-hexahydrobenzofuran-5-yl]pentanoic acid methyl ester
CAS No.:14271-37-5
Molecular Formula:C₁₆H₂₂O₄
Molecular Weight:278.348
Hs Code.:
Mol file:14271-37-5.mol

Synonyms:5-Benzofuranbutanoicacid, 2,3,3a,4,7,7a-hexahydro-g,6-dimethyl-3-methylene-2-oxo-, methyl ester, [3aR-[3aa,5(S*),7aa]]-; 5-Benzofuranbutyric acid,2,3,3aa,4,7,7aa-hexahydro-g,6-dimethyl-3-methylene-2-oxo-,methyl ester (8CI); Ivangulin

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-4-[(3aR)-2-Oxo-3-methylene-6-methyl-2,3,3aα,4,7,7aα-hexahydrobenzofuran-5-yl]pentanoic acid methyl ester

Chemical Property:

PSA：52.60000
LogP:2.78380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S)-4-[(3aR)-2-Oxo-3-methylene-6-methyl-2,3,3aα,4,7,7aα-hexahydrobenzofuran-5-yl]pentanoic acid methyl ester

There total 4 articles about (4S)-4-[(3aR)-2-Oxo-3-methylene-6-methyl-2,3,3aα,4,7,7aα-hexahydrobenzofuran-5-yl]pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73971-65-0
(3aR,7aR)-5-((S)-4-Hydroxy-1-methyl-butyl)-6-methyl-3-methylene-3a,4,7,7a-tetrahydro-3H-benzofuran-2-one

: 14271-37-5
ivangulin

Guidance literature:: Multi-step reaction with 2 steps

1: 8 mg / pyridinium dichromate / dimethylformamide / 10 h / Ambient temperature

2: 12 mg / concentrated H₂SO₄ / 12 h / Ambient temperature

With dipyridinium dichromate; sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo01304a005

Reference yield:

: 73971-69-4
Acetic acid (2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(S)-4-((3aR,7aR)-6-methyl-3-methylene-2-oxo-2,3,3a,4,7,7a-hexahydro-benzofuran-5-yl)-pentyloxy]-tetrahydro-pyran-2-ylmethyl ester

: 14271-37-5
ivangulin

Guidance literature:: Multi-step reaction with 3 steps

1: 25 mg / 6percent aqueous H₂SO₄ / 1.25 h / Heating

2: 8 mg / pyridinium dichromate / dimethylformamide / 10 h / Ambient temperature

3: 12 mg / concentrated H₂SO₄ / 12 h / Ambient temperature

With dipyridinium dichromate; sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo01304a005