(4-BROMOBENZYL)METHYLAMINE

Base Information

• Chemical Name: (4-BROMOBENZYL)METHYLAMINE
• CAS No.: 699-03-6
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• Hs Code.: 2921499090
• Mol file: 699-03-6.mol

Synonyms:Benzylamine,p-bromo-N-methyl- (7CI,8CI);1-(4-Bromophenyl)-N-methylmethanamine;4-Bromo(N-methyl)benzylamine;N-(4-Bromobenzyl)-N-methylamine;

Chemical Property of (4-BROMOBENZYL)METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0478mmHg at 25°C
• Refractive Index: n20/D 1.5650(lit.)
• Boiling Point: 236.3 °C at 760 mmHg
• PKA: 9.52±0.10(Predicted)
• Flash Point: 110 °C
• PSA: 12.03000
• Density: 1.358 g/cm³
• LogP: 2.55940
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Bromophenyl)-N-methylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (4-BROMOBENZYL)METHYLAMINE

There total 8 articles about (4-BROMOBENZYL)METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-bromo-benzaldehyde (1122-91-4) + methylamine (74-89-5) → N-methyl-4-bromobenzylamine (699-03-6)

Guidance literature:

4-bromo-benzaldehyde; methylamine; In methanol; at 65 ℃; for 4h; Autoclave;

With methanol; sodium tetrahydroborate; at 20 ℃; Autoclave;

Reference yield: 87.0%

1-bromomethyl-4-bromobenzene (589-15-1) + methylamine (74-89-5) → N-methyl-4-bromobenzylamine (699-03-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

(4-bromobenzyl)dimethylamine (6274-57-3) → N-methyl-4-bromobenzylamine (699-03-6) + 4-bromo-benzaldehyde (1122-91-4)

Guidance literature:

With iodosylbenzene; meso-tetraphenylporphyrin iron(III) chloride; In benzene;

DOI:10.1039/c39850000064

upstream raw materials:

1-(4-bromophenyl)-N-methylmethanimine

(4-bromobenzyl)dimethylamine

4-bromo-benzaldehyde

methylamine

Downstream raw materials:

C₂₅H₂₄BrFN₂

C₂₆H₂₆BrFN₂

3-[[(4-bromobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one

isopropyl 4-bromobenzyl(methyl)carbamate

Refernces

• 1、 -. "METHODS AND INTERMEDIATES FOR PREPARING RUCAPARIB". Page/Page column 29. . Retrieved 2019/07/17.
• 2、 Nakajima, Minami,Oda, Yukiko,Wada, Takamasa,Minamikawa, Ryo,Shirokane, Kenji,Sato, Takaaki,Chida, Noritaka. "Chemoselective reductive nucleophilic addition to tertiary amides, secondary amides, and N-methoxyamides". supporting information. p. 17565 - 17571. Retrieved 2015/02/19.