2-BROMO-3,4,5-TRIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 2-BROMO-3,4,5-TRIMETHOXYBENZOIC ACID
• CAS No.: 23346-82-9
• Molecular Formula: C10H11 Br O5
• Molecular Weight: 291.098
• Hs Code.: 2918990090
• Mol file: 23346-82-9.mol

Synonyms:2-Bromo-3,4,5-trimethoxybenzoicacid; 2-Bromogallic acid trimethyl ether; NSC 226197; NSC 226216

Chemical Property of 2-BROMO-3,4,5-TRIMETHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 8.11E-06mmHg at 25°C
• Boiling Point: 360.2°Cat760mmHg
• Flash Point: 171.7°C
• PSA: 64.99000
• Density: 1.53g/cm³
• LogP: 2.17310

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-3,4,5-trimethoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-3,4,5-TRIMETHOXYBENZOIC ACID

There total 4 articles about 2-BROMO-3,4,5-TRIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Eudesmic acid (118-41-2) → 2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9)

Guidance literature:

With bromine; In chloroform; water; for 18h; Heating;

DOI:10.1021/ja00252a022

Reference yield:

2-bromo-3,4,5-tri-methoxybenzaldehyde (35274-53-4) → 2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2,3-Dimethyl-2-butene; In water; tert-butyl alcohol; at 20 ℃; for 4h;

DOI:10.1021/jacs.0c12843

Reference yield:

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → 2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.74 g / LiOH / methanol; H₂O / 2 h / 20 °C

2: 96 percent / 1,3-dibromo-5,5-dimethylhydantoin; aq. NaOH / 36 h / 20 °C

With lithium hydroxide; sodium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In methanol; water;

DOI:10.1016/j.tet.2007.07.103

upstream raw materials:

methyl 2-bromo-3,4,5-trimethoxybenzoate

potassium ethoxide

Eudesmic acid

3,4,5-trimethoxybenzoic acid methyl ester

Downstream raw materials:

2,3,4,5-tetramethoxybenzoic acid

3,4,5-trimethoxy-2-phenoxy-benzoic acid

2-hydroxy-3,4,5-trimethoxybenzoic acid

3,4,5-trimethoxyphthalic acid

Refernces

• 1、 Zuo, Ziqing,Kim, Raphael S.,Watson, Donald A.. "Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution". supporting information. p. 1328 - 1333. Retrieved 2021/02/01.
• 2、 -. "Compound and application thereof". Paragraph 0445. . Retrieved 2016/10/09.