benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name)

Base Information

Chemical Name:benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name)
CAS No.:161186-52-3
Molecular Formula:C₄₅H₅₄ClN₇O₆
Molecular Weight:824.42
Hs Code.:
Mol file:161186-52-3.mol

benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name)

Synonyms:SDZ 283005

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Chemical Property of benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name)

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1100.5°Cat760mmHg
Flash Point:619.3°C
Density:1.253g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name)

There total 9 articles about benzyl [(2S)-1-({(2S,3R,4R)-5-({(2S)-1-[(1H-benzimidazol-2-ylmethyl)amino]-3-methyl-1-oxobutan-2-yl}amino)-4-[(4-chlorobenzyl)amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl}amino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 161186-52-3
SDZ 283005

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / N,N'-dicyclohexylcarbodiimide / dioxane / 12 h / Ambient temperature

2: dioxane / Ambient temperature

With dicyclohexyl-carbodiimide; In 1,4-dioxane;
DOI:10.1021/jm00045a013

Reference yield:

: 124818-94-6,116246-06-1
ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate

: 161186-52-3
SDZ 283005

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 120 h / Ambient temperature

2: ethanol / Heating

3: 1N aq. LiOH / tetrahydrofuran / Ambient temperature

4: 1-hydroxybenzotriazole, EDC*HCl / dimethylformamide / Ambient temperature

5: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

6: dioxane / Ambient temperature

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a013

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 161186-52-3
SDZ 283005

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / toluene / 1 h / 80 °C

2: 62 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 120 h / Ambient temperature

3: ethanol / Heating

4: 1N aq. LiOH / tetrahydrofuran / Ambient temperature

5: 1-hydroxybenzotriazole, EDC*HCl / dimethylformamide / Ambient temperature

6: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

7: dioxane / Ambient temperature

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00045a013