62965-10-0

Basic information

• Product Name: Cbz-L-tert-Leucine
• Synonyms: 2S-BenzyloxycarbonylaMino-3,3-diMethylbutyric Acid;3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine;Benzyloxycarbonyl-L-tert-leucine;N-(Benzyloxycarbonyl)-L-tert-butylglycine;N-Benzyloxycarbonyl-tert-leucine;N-Carbobenzoxy-(S)-tert-leucine;(S)-2-(((Benzyloxy)carbonyl)aMino)-3,3-diMethylbutanoic acid;(2S)-2-([(Benzyloxy)Carbonyl]AMino)-3,3-DiMethylbutanoic Acid DicyclohexylaMine Salt
• CAS NO: 62965-10-0
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.3
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acid Derivatives;Leucine [Leu, L];Amino Acids & Deriv.;CHIRAL CHEMICALS;Amino Acids & Derivatives
• Mol File: 62965-10-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 436.4 ºC at 760 mmHg
• Flash Point: 217.7 ºC
• Appearance: White powder
• Density: 1.16 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: Cbz-L-tert-Leucine(CAS DataBase Reference)
• NIST Chemistry Reference: Cbz-L-tert-Leucine(62965-10-0)
• EPA Substance Registry System: Cbz-L-tert-Leucine(62965-10-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 62965-10-0(Hazardous Substances Data)

Usage

Uses

Cbz-L-tert-Leucine is a leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors.

InChI:InChI=1/C14H19NO4/c1-14(2,3)11(12(16)17)15-13(18)19-9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m1/s1

Upstream product

• 20859-02-3 L-tert-Leucine 
• 501-53-1 benzyl chloroformate 
• 62965-57-5 (±)-2-amino-3,3-dimethylbutanamide 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 621-84-1 O-benzyl carbamate 
• 13795-24-9 benzyl 4-nitrophenyl carbonate 
• 100-51-6 benzyl alcohol 
• 62965-37-1 (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid dicyclohexylammonium salt 
• 68222-59-3 2(S)-{(benzyloxycarbonyl)amino}-3,3-dimethylbutanoic acid 

Downstream Products

• 148743-41-3 2(S)-<<(benzyloxy)carbonyl>amino>-3,3-dimethylbutanoic acid N-hydroxysuccinimido ester 
• 214286-93-8 (S)-4-benzyloxycarbonylamino-5,5-dimethyl-3-oxo-hexanoic acid tert-butyl ester 
• 148054-84-6 (S)-1-[N-(benzyloxycarbonyl)-2-(tert-butyl)glycyl]piperidine 
• 609367-72-8 [(S)-2,2-Dimethyl-1-(pyrrolidine-1-carbonyl)-propyl]-carbamic acid benzyl ester 
• 141970-45-8 (S)-2-benzyloxycarbonylamino-3,3-dimethyl-butyric acid methyl ester 
• 609367-74-0 [(S)-2,2-Dimethyl-1-(4-methyl-piperazine-1-carbonyl)-propyl]-carbamic acid benzyl ester 
• 609367-80-8 [1-(3,4-dihydro-2H-quinoline-1-carbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester 
• 609367-77-3 1-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-piperidine-4-carboxylic acid ethyl ester 
• 609367-78-4 [(S)-1-(Cyclohexyl-methyl-carbamoyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester 
• 609367-79-5 [(S)-2,2-Dimethyl-1-(octahydro-quinoline-1-carbonyl)-propyl]-carbamic acid benzyl ester 
• 609367-76-2 [(S)-1-(4-Acetyl-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester 
• 615583-05-6 C₂₇H₄₀N₂O₅ 
• 372199-34-3 Cbz-tBu-Gly-NH₂ 
• 325796-51-8 [1S-(4-Hydroxy-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester 

Relevant articles and documents

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