4,5-DICHLORO-1-METHYLIMIDAZOLE

Base Information

• Chemical Name: 4,5-DICHLORO-1-METHYLIMIDAZOLE
• CAS No.: 1192-53-6
• Molecular Formula: C4H4 Cl2 N2
• Molecular Weight: 150.995
• Hs Code.: 2933290090
• Mol file: 1192-53-6.mol

Synonyms:Imidazole,4,5-dichloro-1-methyl- (7CI,8CI); 4,5-Dichloro-1-methyl-1H-imidazole;4,5-Dichloro-1-methylimidazole

Chemical Property of 4,5-DICHLORO-1-METHYLIMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.00446mmHg at 25°C
• Melting Point: 53-55oC
• Boiling Point: 286.8°Cat760mmHg
• Flash Point: 127.2°C
• PSA: 17.82000
• Density: 1.49g/cm³
• LogP: 1.72690
• Water Solubility.: Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5-DICHLORO-1-METHYLIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DICHLORO-1-METHYLIMIDAZOLE

There total 2 articles about 4,5-DICHLORO-1-METHYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4,5-dichloroimidazole (15965-30-7) + methyl iodide (74-88-4) → 4,5-dichloro-1-methyl-1H-imidazole (1192-53-6)

Guidance literature:

4,5-dichloroimidazole; With potassium hydroxide; In acetonitrile; at 20 ℃; for 2h;

methyl iodide; In acetonitrile; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/jm0708679

Reference yield:

→ 4,5-dichloro-1-methyl-1H-imidazole (1192-53-6)

Guidance literature:

N,N'-Dimethyloxamid, PCl5 (95-98grad), neben 5-Chlor-1-methylimidazol (I);

Reference yield: 99.0%

Cyclohexanethiol (1569-69-3) + 4,5-dichloro-1-methyl-1H-imidazole (1192-53-6) → 4-chloro-5-(cyclohexylthio)-1-methyl-1H-imidazole

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In N,N-dimethyl acetamide; at 20 ℃; for 16h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.0c01630

upstream raw materials:

4,5-dichloroimidazole

methyl iodide

Downstream raw materials:

4,5-dichloro-1-methyl-3-(4-nitrobenzyl)imidazolium bromide

4,5-dichloro-1-methyl-3-benzylimidazolium bromide

Refernces

• 1、 Hindi, Khadijah M.,Siciliano, Tammy J.,Durmus, Semih,Panzner, Matthew J.,Medvetz, Doug A.,Reddy, D. Venkat,Hogue, Lisa A.,Hovis, Christine E.,Hilliard, Julia K.,Mallet, Rebekah J.,Tessier, Claire A.,Cannon, Carolyn L.,Youngs, Wiley J.. "Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes". . p. 1577 - 1583. Retrieved 2008.
• 2、 Patil, Siddappa,Deally, Anthony,Gleeson, Brendan,Hackenberg, Frauke,Müller-Bunz, Helge,Paradisi, Francesca,Tacke, Matthias. "Synthesis, cytotoxicity and antibacterial studies of novel symmetrically and non-symmetrically p-nitrobenzyl-substituted N-heterocyclic carbene-silver(i) acetate complexes". experimental part. p. 386 - 396. Retrieved 2011/05/05.