ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE

Base Information

• Chemical Name: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE
• CAS No.: 4497-08-9
• Molecular Formula: C22H21 Cl N2 O7
• Molecular Weight: 497.33
• Mol file: 4497-08-9.mol

Synonyms:2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-(6CI,7CI,8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,[4S-(4a,4aa,12aa)]-; Anhydroaureomycin; Anhydrochlortetracycline; Anhydrochlortetracyline;Aureomycin, anhydro-; Chlortetracycline, anhydro-

Chemical Property of ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.21E-16mmHg at 25°C
• Melting Point: 250 °C
• Boiling Point: 623°Cat760mmHg
• Flash Point: 330.6°C
• PSA: 161.39000
• Density: g/cm³
• LogP: 2.61150
• Storage Temp.: -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Anti-acta1b antibody produced in rabbit affinity isolated antibody, buffered aqueous solution ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 63-36
• Safety Statements: 36/37/39-26

MSDS Files:

Useful:

• Uses: Anhydrochlortetracycline is a degradation product of chlortetracycline formed by acid-catalysed isomerisation of the dimethylamino group at C4. Anhydrochlortetracycline exhibits little antibiotic activity but its abundance is indicative of poor storage and handling of chlortetracycline.

Technology Process of ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE

There total 7 articles about ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Chlortetracycline (57-62-5) → (4S,4aS,12aS)-7-chloro-4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide (4497-08-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01139a538

Reference yield:

(4R,4aR,5aR,6S,12aR)-7-Chloro-4-dimethylamino-3,10,12,12a-tetrahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide → Anhydro-aureomycin (4497-08-9,81163-11-3,146064-04-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane;

Reference yield:

(4R,4aR,5aR,6S,12aR)-4-Amino-7-chloro-3,12,12a-trihydroxy-10-methoxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid tert-butylamide → Anhydro-aureomycin (4497-08-9,81163-11-3,146064-04-2)

Guidance literature:

Multi-step reaction with 3 steps

2: aq. HBr

3: DDQ / dioxane

With hydrogen bromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane;

upstream raw materials:

Chlortetracycline

hydrogenchloride

Downstream raw materials:

7-Chlor-5a(11a)-dehydro-tetracyclin