3-Butenenitrile, 2-(methylphenylamino)-4-phenyl-, (E)-

Base Information

• Chemical Name: 3-Butenenitrile, 2-(methylphenylamino)-4-phenyl-, (E)-
• CAS No.: 120568-26-5
• Molecular Formula: C17H16N2
• Molecular Weight: 248.327
• Mol file: 120568-26-5.mol

Synonyms:

Chemical Property of 3-Butenenitrile, 2-(methylphenylamino)-4-phenyl-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butenenitrile, 2-(methylphenylamino)-4-phenyl-, (E)-

There total 2 articles about 3-Butenenitrile, 2-(methylphenylamino)-4-phenyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-phenylpropenal (14371-10-9) + potassium cyanide (151-50-8) + N-methylaniline (100-61-8) → (E)-2-(methyl(phenyl)amino)-4-phenylbut-3-enenitrile (120568-26-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 0 ℃; for 2h;

DOI:10.1039/c39880001385

Reference yield:

(E)-3-phenylpropenal (14371-10-9) + trimethylsilyl cyanide (7677-24-9) + N-methylaniline (100-61-8) → (E)-2-(methyl(phenyl)amino)-4-phenylbut-3-enenitrile (120568-26-5)

Guidance literature:

DOI:10.1002/anie.201900442

Reference yield: 42.0%

(E)-2-(methyl(phenyl)amino)-4-phenylbut-3-enenitrile (120568-26-5) → N-methyl-N-phenyl-3-phenylpropanamide (18859-20-6) + benzonitrile (100-47-0)

Guidance literature:

With palladium diacetate; iodobenzene; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

DOI:10.1055/s-1997-5783

upstream raw materials:

(E)-3-phenylpropenal

potassium cyanide

N-methylaniline

trimethylsilyl cyanide

Downstream raw materials:

(Z)-2-(N-methylanilino)-4-phenyl-2-butenenitrile

(Z)-7-chloro-2-(N-methylanilino)-4-phenyl-2-heptenenitrile

7-bromo-2-(N-methylanilino)-4-phenyl-2-heptenenitrile

8-bromo-2-N-methylanilino-4-phenyl-oct-2-enenitrile

Refernces

• 1、 Fang, Jim-Min,Chang, Han-Ting,Lin, Chun-Cheng. "Intramolecular Free Radical Cyclisation of α-Anilino Alkenenitriles". . p. 1385 - 1386. Retrieved 2007/10/02.